Small molecule targeting CELF1 RNA-binding activity to control HSC activation and liver fibrosis

CUGBP Elav-like family member 1 (CELF1), an RNA-binding protein (RBP), plays important roles in the pathogenesis of diseases such as myotonic dystrophy, liver fibrosis and cancers. However, targeting CELF1 is still a challenge, as RBPs are considered largely undruggable. Here, we discovered that com...

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Detalles Bibliográficos
Autores principales: Tan, Yang, Sun, Xueqing, Xu, Yizhu, Tang, Bingjie, Xu, Shuaiqi, Lu, Dong, Ye, Yan, Luo, Xiaomin, Diao, Xu, Li, Fulong, Wang, Tianyi, Chen, Jiayu, Xu, Qiang, Wu, Xingxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934652/
https://www.ncbi.nlm.nih.gov/pubmed/35234905
http://dx.doi.org/10.1093/nar/gkac139

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