Persistent DNA damage associated with ATM kinase deficiency promotes microglial dysfunction

The autosomal recessive genome instability disorder Ataxia–telangiectasia, caused by mutations in ATM kinase, is characterized by the progressive loss of cerebellar neurons. We find that DNA damage associated with ATM loss results in dysfunctional behaviour of human microglia, immune cells of the ce...

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Detalles Bibliográficos
Autores principales: Bourseguin, Julie, Cheng, Wen, Talbot, Emily, Hardy, Liana, Lai, Jenny, Jeffries, Ailsa M, Lodato, Michael A, Lee, Eunjung Alice, Khoronenkova, Svetlana V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934660/
https://www.ncbi.nlm.nih.gov/pubmed/35212385
http://dx.doi.org/10.1093/nar/gkac104

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934660/
https://www.ncbi.nlm.nih.gov/pubmed/35212385
http://dx.doi.org/10.1093/nar/gkac104

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