AT-hook peptides bind the major and minor groove of AT-rich DNA duplexes

The mammalian high mobility group protein AT-hook 2 (HMGA2) houses three motifs that preferentially bind short stretches of AT-rich DNA regions. These DNA binding motifs, known as ‘AT-hooks’, are traditionally characterized as being unstructured. Upon binding to AT-rich DNA, they form ordered assemb...

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Detalles Bibliográficos
Autores principales: Garabedian, Alyssa, Jeanne Dit Fouque, Kevin, Chapagain, Prem P, Leng, Fenfei, Fernandez-Lima, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934665/
https://www.ncbi.nlm.nih.gov/pubmed/35212375
http://dx.doi.org/10.1093/nar/gkac115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934665/
https://www.ncbi.nlm.nih.gov/pubmed/35212375
http://dx.doi.org/10.1093/nar/gkac115

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