Inflammaging at the Time of COVID-19

Severe coronavirus disease 2019 (COVID-19) is associated with overproduction of proinflammatory cytokines. The ensuing cytokine storm contributes to the development of severe pneumonia and, possibly, to long-term symptom persistence (long COVID). The chronic state of low-grade inflammation that acco...

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Autores principales: Zazzara, Maria Beatrice, Bellieni, Andrea, Calvani, Riccardo, Coelho-Junior, Hélio Jose, Picca, Anna, Marzetti, Emanuele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934712/
https://www.ncbi.nlm.nih.gov/pubmed/35868667
http://dx.doi.org/10.1016/j.cger.2022.03.003
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author Zazzara, Maria Beatrice
Bellieni, Andrea
Calvani, Riccardo
Coelho-Junior, Hélio Jose
Picca, Anna
Marzetti, Emanuele
author_facet Zazzara, Maria Beatrice
Bellieni, Andrea
Calvani, Riccardo
Coelho-Junior, Hélio Jose
Picca, Anna
Marzetti, Emanuele
author_sort Zazzara, Maria Beatrice
collection PubMed
description Severe coronavirus disease 2019 (COVID-19) is associated with overproduction of proinflammatory cytokines. The ensuing cytokine storm contributes to the development of severe pneumonia and, possibly, to long-term symptom persistence (long COVID). The chronic state of low-grade inflammation that accompanies aging (inflammaging) might predispose older adults to severe COVID-19. Inflammaging may also contribute to symptom persistence following acute COVID-19. Antiinflammatory drugs and immunomodulatory agents can achieve significant therapeutic gain during acute COVID-19. Lifestyle interventions (eg, physical activity, diet) may be proposed as strategies to counteract inflammation and mitigate long-term symptom persistence.
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spelling pubmed-89347122022-03-21 Inflammaging at the Time of COVID-19 Zazzara, Maria Beatrice Bellieni, Andrea Calvani, Riccardo Coelho-Junior, Hélio Jose Picca, Anna Marzetti, Emanuele Clin Geriatr Med Article Severe coronavirus disease 2019 (COVID-19) is associated with overproduction of proinflammatory cytokines. The ensuing cytokine storm contributes to the development of severe pneumonia and, possibly, to long-term symptom persistence (long COVID). The chronic state of low-grade inflammation that accompanies aging (inflammaging) might predispose older adults to severe COVID-19. Inflammaging may also contribute to symptom persistence following acute COVID-19. Antiinflammatory drugs and immunomodulatory agents can achieve significant therapeutic gain during acute COVID-19. Lifestyle interventions (eg, physical activity, diet) may be proposed as strategies to counteract inflammation and mitigate long-term symptom persistence. Elsevier Inc. 2022-08 2022-03-21 /pmc/articles/PMC8934712/ /pubmed/35868667 http://dx.doi.org/10.1016/j.cger.2022.03.003 Text en © 2022 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Zazzara, Maria Beatrice
Bellieni, Andrea
Calvani, Riccardo
Coelho-Junior, Hélio Jose
Picca, Anna
Marzetti, Emanuele
Inflammaging at the Time of COVID-19
title Inflammaging at the Time of COVID-19
title_full Inflammaging at the Time of COVID-19
title_fullStr Inflammaging at the Time of COVID-19
title_full_unstemmed Inflammaging at the Time of COVID-19
title_short Inflammaging at the Time of COVID-19
title_sort inflammaging at the time of covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934712/
https://www.ncbi.nlm.nih.gov/pubmed/35868667
http://dx.doi.org/10.1016/j.cger.2022.03.003
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