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Epidemiology, clinical ramifications, and cellular pathogenesis of COVID-19 mRNA-vaccination-induced adverse cardiovascular outcomes: A state-of-the-heart review
The coronavirus disease 2019 (COVID-19) has overwhelming healthcare systems globally. To date, a myriad of therapeutic regimens has been employed in an attempt to curb the ramifications of a severe COVID-19 infection. Amidst the ongoing pandemic, the advent and efficacious uptake of COVID-19 vaccina...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Authors. Published by Elsevier Masson SAS.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934717/ https://www.ncbi.nlm.nih.gov/pubmed/35325848 http://dx.doi.org/10.1016/j.biopha.2022.112843 |
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author | Almas, Talal Rehman, Sarah Mansour, Eyad Khedro, Tarek Alansari, Ali Malik, Jahanzeb Alshareef, Norah Nagarajan, Vikneswaran Raj Al-Awaid, Abdulla Hussain Alsufyani, Reema Alsufyani, Majid Rifai, Ali Alzahrani, Ahlam Nagarajan, Dhineswaran Raj Abdullatif, Tala Gunasaegaram, Varman Alzadjali, Enaam Subramanian, Arthi Rahman, Abida Sattar, Yasar Galo, Jason Virk, Hafeez Ul Hassan Alraies, M. Chadi |
author_facet | Almas, Talal Rehman, Sarah Mansour, Eyad Khedro, Tarek Alansari, Ali Malik, Jahanzeb Alshareef, Norah Nagarajan, Vikneswaran Raj Al-Awaid, Abdulla Hussain Alsufyani, Reema Alsufyani, Majid Rifai, Ali Alzahrani, Ahlam Nagarajan, Dhineswaran Raj Abdullatif, Tala Gunasaegaram, Varman Alzadjali, Enaam Subramanian, Arthi Rahman, Abida Sattar, Yasar Galo, Jason Virk, Hafeez Ul Hassan Alraies, M. Chadi |
author_sort | Almas, Talal |
collection | PubMed |
description | The coronavirus disease 2019 (COVID-19) has overwhelming healthcare systems globally. To date, a myriad of therapeutic regimens has been employed in an attempt to curb the ramifications of a severe COVID-19 infection. Amidst the ongoing pandemic, the advent and efficacious uptake of COVID-19 vaccination has significantly reduced disease-related hospitalizations and mortality. Nevertheless, many side-effects are being reported after COVID-19 vaccinations and myocarditis is the most commonly reported sequelae post vaccination. Majority of these diseases are associated with COVID-19 mRNA vaccines. Various studies have established a temporal relationship between these complications, yet the causality and the underlying pathogenesis remain hypothetical. In this review, we aim to critically appraise the available literature regarding the cardiovascular side effects of the various mRNA vaccines and the associated pathophysiology. |
format | Online Article Text |
id | pubmed-8934717 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Authors. Published by Elsevier Masson SAS. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89347172022-03-21 Epidemiology, clinical ramifications, and cellular pathogenesis of COVID-19 mRNA-vaccination-induced adverse cardiovascular outcomes: A state-of-the-heart review Almas, Talal Rehman, Sarah Mansour, Eyad Khedro, Tarek Alansari, Ali Malik, Jahanzeb Alshareef, Norah Nagarajan, Vikneswaran Raj Al-Awaid, Abdulla Hussain Alsufyani, Reema Alsufyani, Majid Rifai, Ali Alzahrani, Ahlam Nagarajan, Dhineswaran Raj Abdullatif, Tala Gunasaegaram, Varman Alzadjali, Enaam Subramanian, Arthi Rahman, Abida Sattar, Yasar Galo, Jason Virk, Hafeez Ul Hassan Alraies, M. Chadi Biomed Pharmacother Review The coronavirus disease 2019 (COVID-19) has overwhelming healthcare systems globally. To date, a myriad of therapeutic regimens has been employed in an attempt to curb the ramifications of a severe COVID-19 infection. Amidst the ongoing pandemic, the advent and efficacious uptake of COVID-19 vaccination has significantly reduced disease-related hospitalizations and mortality. Nevertheless, many side-effects are being reported after COVID-19 vaccinations and myocarditis is the most commonly reported sequelae post vaccination. Majority of these diseases are associated with COVID-19 mRNA vaccines. Various studies have established a temporal relationship between these complications, yet the causality and the underlying pathogenesis remain hypothetical. In this review, we aim to critically appraise the available literature regarding the cardiovascular side effects of the various mRNA vaccines and the associated pathophysiology. The Authors. Published by Elsevier Masson SAS. 2022-05 2022-03-21 /pmc/articles/PMC8934717/ /pubmed/35325848 http://dx.doi.org/10.1016/j.biopha.2022.112843 Text en © 2022 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Review Almas, Talal Rehman, Sarah Mansour, Eyad Khedro, Tarek Alansari, Ali Malik, Jahanzeb Alshareef, Norah Nagarajan, Vikneswaran Raj Al-Awaid, Abdulla Hussain Alsufyani, Reema Alsufyani, Majid Rifai, Ali Alzahrani, Ahlam Nagarajan, Dhineswaran Raj Abdullatif, Tala Gunasaegaram, Varman Alzadjali, Enaam Subramanian, Arthi Rahman, Abida Sattar, Yasar Galo, Jason Virk, Hafeez Ul Hassan Alraies, M. Chadi Epidemiology, clinical ramifications, and cellular pathogenesis of COVID-19 mRNA-vaccination-induced adverse cardiovascular outcomes: A state-of-the-heart review |
title | Epidemiology, clinical ramifications, and cellular pathogenesis of COVID-19 mRNA-vaccination-induced adverse cardiovascular outcomes: A state-of-the-heart review |
title_full | Epidemiology, clinical ramifications, and cellular pathogenesis of COVID-19 mRNA-vaccination-induced adverse cardiovascular outcomes: A state-of-the-heart review |
title_fullStr | Epidemiology, clinical ramifications, and cellular pathogenesis of COVID-19 mRNA-vaccination-induced adverse cardiovascular outcomes: A state-of-the-heart review |
title_full_unstemmed | Epidemiology, clinical ramifications, and cellular pathogenesis of COVID-19 mRNA-vaccination-induced adverse cardiovascular outcomes: A state-of-the-heart review |
title_short | Epidemiology, clinical ramifications, and cellular pathogenesis of COVID-19 mRNA-vaccination-induced adverse cardiovascular outcomes: A state-of-the-heart review |
title_sort | epidemiology, clinical ramifications, and cellular pathogenesis of covid-19 mrna-vaccination-induced adverse cardiovascular outcomes: a state-of-the-heart review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934717/ https://www.ncbi.nlm.nih.gov/pubmed/35325848 http://dx.doi.org/10.1016/j.biopha.2022.112843 |
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