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HFA‐PEFF score: prognosis in patients with preserved ejection fraction after transcatheter aortic valve implantation

AIMS: Many transcatheter aortic valve implantation (TAVI) candidates have underlying heart failure with preserved ejection fraction (HFpEF) in addition to symptomatic aortic stenosis. Diagnosis of HFpEF is challenging. The Heart Failure Association of the European Society of Cardiology proposed the...

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Autores principales: Seoudy, Hatim, von Eberstein, Mira, Frank, Johanne, Thomann, Maren, Puehler, Thomas, Lutter, Georg, Lutz, Matthias, Bramlage, Peter, Frey, Norbert, Saad, Mohammed, Frank, Derk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934930/
https://www.ncbi.nlm.nih.gov/pubmed/35092186
http://dx.doi.org/10.1002/ehf2.13774
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author Seoudy, Hatim
von Eberstein, Mira
Frank, Johanne
Thomann, Maren
Puehler, Thomas
Lutter, Georg
Lutz, Matthias
Bramlage, Peter
Frey, Norbert
Saad, Mohammed
Frank, Derk
author_facet Seoudy, Hatim
von Eberstein, Mira
Frank, Johanne
Thomann, Maren
Puehler, Thomas
Lutter, Georg
Lutz, Matthias
Bramlage, Peter
Frey, Norbert
Saad, Mohammed
Frank, Derk
author_sort Seoudy, Hatim
collection PubMed
description AIMS: Many transcatheter aortic valve implantation (TAVI) candidates have underlying heart failure with preserved ejection fraction (HFpEF) in addition to symptomatic aortic stenosis. Diagnosis of HFpEF is challenging. The Heart Failure Association of the European Society of Cardiology proposed the HFA‐PEFF score as part of a novel diagnostic algorithm. This study assessed the prognostic value of the HFA‐PEFF score in patients with preserved ejection fraction after TAVI. METHODS AND RESULTS: This single‐centre study included 570 consecutive TAVI patients with a preserved left ventricular ejection fraction of ≥50%. Patients with an HFA‐PEFF score of ≥5 [n = 239 (41.9%)] were compared with those with <5 points [n = 331 (58.1%)]. The primary outcome was a composite of all‐cause mortality or first heart failure rehospitalization within 1 year after TAVI. Secondary endpoints were the individual components of the primary outcome. Patients with an HFA‐PEFF score ≥ 5 had higher rates of comorbidities commonly associated with HFpEF, a higher rate of new pacemaker implantation after TAVI, were at increased risk of the primary composite endpoint (25.5% vs. 10.0%, P < 0.001), and rehospitalization for heart failure (11.7% vs. 3.9%, P < 0.001). Multivariable analysis confirmed an HFA‐PEFF score ≥ 5 as an independent risk factor for the composite endpoint [hazard ratio 2.70, 95% confidence interval (CI) 1.70–4.28, P < 0.001] and for all‐cause mortality (hazard ratio 2.58, 95% CI 1.46–4.53, P = 0.001). CONCLUSION: The HFA‐PEFF score is associated with all‐cause mortality and heart failure rehospitalization in patients with preserved ejection fraction after TAVI. This practical tool can easily be incorporated into risk stratification algorithms for TAVI patients.
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spelling pubmed-89349302022-03-24 HFA‐PEFF score: prognosis in patients with preserved ejection fraction after transcatheter aortic valve implantation Seoudy, Hatim von Eberstein, Mira Frank, Johanne Thomann, Maren Puehler, Thomas Lutter, Georg Lutz, Matthias Bramlage, Peter Frey, Norbert Saad, Mohammed Frank, Derk ESC Heart Fail Original Articles AIMS: Many transcatheter aortic valve implantation (TAVI) candidates have underlying heart failure with preserved ejection fraction (HFpEF) in addition to symptomatic aortic stenosis. Diagnosis of HFpEF is challenging. The Heart Failure Association of the European Society of Cardiology proposed the HFA‐PEFF score as part of a novel diagnostic algorithm. This study assessed the prognostic value of the HFA‐PEFF score in patients with preserved ejection fraction after TAVI. METHODS AND RESULTS: This single‐centre study included 570 consecutive TAVI patients with a preserved left ventricular ejection fraction of ≥50%. Patients with an HFA‐PEFF score of ≥5 [n = 239 (41.9%)] were compared with those with <5 points [n = 331 (58.1%)]. The primary outcome was a composite of all‐cause mortality or first heart failure rehospitalization within 1 year after TAVI. Secondary endpoints were the individual components of the primary outcome. Patients with an HFA‐PEFF score ≥ 5 had higher rates of comorbidities commonly associated with HFpEF, a higher rate of new pacemaker implantation after TAVI, were at increased risk of the primary composite endpoint (25.5% vs. 10.0%, P < 0.001), and rehospitalization for heart failure (11.7% vs. 3.9%, P < 0.001). Multivariable analysis confirmed an HFA‐PEFF score ≥ 5 as an independent risk factor for the composite endpoint [hazard ratio 2.70, 95% confidence interval (CI) 1.70–4.28, P < 0.001] and for all‐cause mortality (hazard ratio 2.58, 95% CI 1.46–4.53, P = 0.001). CONCLUSION: The HFA‐PEFF score is associated with all‐cause mortality and heart failure rehospitalization in patients with preserved ejection fraction after TAVI. This practical tool can easily be incorporated into risk stratification algorithms for TAVI patients. John Wiley and Sons Inc. 2022-01-29 /pmc/articles/PMC8934930/ /pubmed/35092186 http://dx.doi.org/10.1002/ehf2.13774 Text en © 2022 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Articles
Seoudy, Hatim
von Eberstein, Mira
Frank, Johanne
Thomann, Maren
Puehler, Thomas
Lutter, Georg
Lutz, Matthias
Bramlage, Peter
Frey, Norbert
Saad, Mohammed
Frank, Derk
HFA‐PEFF score: prognosis in patients with preserved ejection fraction after transcatheter aortic valve implantation
title HFA‐PEFF score: prognosis in patients with preserved ejection fraction after transcatheter aortic valve implantation
title_full HFA‐PEFF score: prognosis in patients with preserved ejection fraction after transcatheter aortic valve implantation
title_fullStr HFA‐PEFF score: prognosis in patients with preserved ejection fraction after transcatheter aortic valve implantation
title_full_unstemmed HFA‐PEFF score: prognosis in patients with preserved ejection fraction after transcatheter aortic valve implantation
title_short HFA‐PEFF score: prognosis in patients with preserved ejection fraction after transcatheter aortic valve implantation
title_sort hfa‐peff score: prognosis in patients with preserved ejection fraction after transcatheter aortic valve implantation
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934930/
https://www.ncbi.nlm.nih.gov/pubmed/35092186
http://dx.doi.org/10.1002/ehf2.13774
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