Case Report: Interest of Positron Emission Tomography in Pediatric Small Vessel Primary Angiitis of the Central Nervous System

Primary angiitis of the central nervous system (PACNS) is a rare inflammatory disease affecting central nervous system vessels. The diagnosis, which requires confirmation by brain biopsy, remains challenging due to unspecific clinical presentation and low specificity of imaging and laboratory exams....

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Detalles Bibliográficos
Autores principales: Belcour, Morgane, Dontaine, Pauline, Monier, Anne, Lebrun, Laetitia, Salmon, Isabelle, De Witte, Olivier, Goldman, Serge, De Tiège, Xavier, Aeby, Alec
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pediatrics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8935040/
https://www.ncbi.nlm.nih.gov/pubmed/35321014
http://dx.doi.org/10.3389/fped.2022.794294
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author Belcour, Morgane
Dontaine, Pauline
Monier, Anne
Lebrun, Laetitia
Salmon, Isabelle
De Witte, Olivier
Goldman, Serge
De Tiège, Xavier
Aeby, Alec
author_facet Belcour, Morgane
Dontaine, Pauline
Monier, Anne
Lebrun, Laetitia
Salmon, Isabelle
De Witte, Olivier
Goldman, Serge
De Tiège, Xavier
Aeby, Alec
author_sort Belcour, Morgane
collection PubMed
description Primary angiitis of the central nervous system (PACNS) is a rare inflammatory disease affecting central nervous system vessels. The diagnosis, which requires confirmation by brain biopsy, remains challenging due to unspecific clinical presentation and low specificity of imaging and laboratory exams. In these two pediatric biopsy-proven cases of svPACNS we demonstrate that brain positron emission tomography (PET) show a high metabolic activity that extends beyond brain MRI abnormalities. Therefore, combining MRI and PET abnormalities to adequately guide brain biopsy might increase the diagnostic yield of this rare condition.
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spelling pubmed-89350402022-03-22 Case Report: Interest of Positron Emission Tomography in Pediatric Small Vessel Primary Angiitis of the Central Nervous System Belcour, Morgane Dontaine, Pauline Monier, Anne Lebrun, Laetitia Salmon, Isabelle De Witte, Olivier Goldman, Serge De Tiège, Xavier Aeby, Alec Front Pediatr Pediatrics Primary angiitis of the central nervous system (PACNS) is a rare inflammatory disease affecting central nervous system vessels. The diagnosis, which requires confirmation by brain biopsy, remains challenging due to unspecific clinical presentation and low specificity of imaging and laboratory exams. In these two pediatric biopsy-proven cases of svPACNS we demonstrate that brain positron emission tomography (PET) show a high metabolic activity that extends beyond brain MRI abnormalities. Therefore, combining MRI and PET abnormalities to adequately guide brain biopsy might increase the diagnostic yield of this rare condition. Frontiers Media S.A. 2022-03-07 /pmc/articles/PMC8935040/ /pubmed/35321014 http://dx.doi.org/10.3389/fped.2022.794294 Text en Copyright © 2022 Belcour, Dontaine, Monier, Lebrun, Salmon, De Witte, Goldman, De Tiège and Aeby. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Belcour, Morgane
Dontaine, Pauline
Monier, Anne
Lebrun, Laetitia
Salmon, Isabelle
De Witte, Olivier
Goldman, Serge
De Tiège, Xavier
Aeby, Alec
Case Report: Interest of Positron Emission Tomography in Pediatric Small Vessel Primary Angiitis of the Central Nervous System
title Case Report: Interest of Positron Emission Tomography in Pediatric Small Vessel Primary Angiitis of the Central Nervous System
title_full Case Report: Interest of Positron Emission Tomography in Pediatric Small Vessel Primary Angiitis of the Central Nervous System
title_fullStr Case Report: Interest of Positron Emission Tomography in Pediatric Small Vessel Primary Angiitis of the Central Nervous System
title_full_unstemmed Case Report: Interest of Positron Emission Tomography in Pediatric Small Vessel Primary Angiitis of the Central Nervous System
title_short Case Report: Interest of Positron Emission Tomography in Pediatric Small Vessel Primary Angiitis of the Central Nervous System
title_sort case report: interest of positron emission tomography in pediatric small vessel primary angiitis of the central nervous system
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8935040/
https://www.ncbi.nlm.nih.gov/pubmed/35321014
http://dx.doi.org/10.3389/fped.2022.794294
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