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Dysregulation of Translation in TDP-43 Proteinopathies: Deficits in the RNA Supply Chain and Local Protein Production

Local control of gene expression provides critical mechanisms for regulating development, maintenance and plasticity in the nervous system. Among the strategies known to govern gene expression locally, mRNA transport and translation have emerged as essential for a neuron’s ability to navigate develo...

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Detalles Bibliográficos
Autores principales: Bjork, Reed T., Mortimore, Nicholas P., Loganathan, Suvithanandhini, Zarnescu, Daniela C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8935057/
https://www.ncbi.nlm.nih.gov/pubmed/35321094
http://dx.doi.org/10.3389/fnins.2022.840357