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Mitochondria Related Cell Death Modalities and Disease

Mitochondria are well known as the centre of energy metabolism in eukaryotic cells. However, they can not only generate ATP through the tricarboxylic acid cycle and oxidative phosphorylation but also control the mode of cell death through various mechanisms, especially regulated cell death (RCD), su...

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Autores principales: Tian, Chuwen, Liu, Yifan, Li, Zhuoshu, Zhu, Ping, Zhao, Mingyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8935059/
https://www.ncbi.nlm.nih.gov/pubmed/35321239
http://dx.doi.org/10.3389/fcell.2022.832356
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author Tian, Chuwen
Liu, Yifan
Li, Zhuoshu
Zhu, Ping
Zhao, Mingyi
author_facet Tian, Chuwen
Liu, Yifan
Li, Zhuoshu
Zhu, Ping
Zhao, Mingyi
author_sort Tian, Chuwen
collection PubMed
description Mitochondria are well known as the centre of energy metabolism in eukaryotic cells. However, they can not only generate ATP through the tricarboxylic acid cycle and oxidative phosphorylation but also control the mode of cell death through various mechanisms, especially regulated cell death (RCD), such as apoptosis, mitophagy, NETosis, pyroptosis, necroptosis, entosis, parthanatos, ferroptosis, alkaliptosis, autosis, clockophagy and oxeiptosis. These mitochondria-associated modes of cell death can lead to a variety of diseases. During cell growth, these modes of cell death are programmed, meaning that they can be induced or predicted. Mitochondria-based treatments have been shown to be effective in many trials. Therefore, mitochondria have great potential for the treatment of many diseases. In this review, we discuss how mitochondria are involved in modes of cell death, as well as basic research and the latest clinical progress in related fields. We also detail a variety of organ system diseases related to mitochondria, including nervous system diseases, cardiovascular diseases, digestive system diseases, respiratory diseases, endocrine diseases, urinary system diseases and cancer. We highlight the role that mitochondria play in these diseases and suggest possible therapeutic directions as well as pressing issues that need to be addressed today. Because of the key role of mitochondria in cell death, a comprehensive understanding of mitochondria can help provide more effective strategies for clinical treatment.
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spelling pubmed-89350592022-03-22 Mitochondria Related Cell Death Modalities and Disease Tian, Chuwen Liu, Yifan Li, Zhuoshu Zhu, Ping Zhao, Mingyi Front Cell Dev Biol Cell and Developmental Biology Mitochondria are well known as the centre of energy metabolism in eukaryotic cells. However, they can not only generate ATP through the tricarboxylic acid cycle and oxidative phosphorylation but also control the mode of cell death through various mechanisms, especially regulated cell death (RCD), such as apoptosis, mitophagy, NETosis, pyroptosis, necroptosis, entosis, parthanatos, ferroptosis, alkaliptosis, autosis, clockophagy and oxeiptosis. These mitochondria-associated modes of cell death can lead to a variety of diseases. During cell growth, these modes of cell death are programmed, meaning that they can be induced or predicted. Mitochondria-based treatments have been shown to be effective in many trials. Therefore, mitochondria have great potential for the treatment of many diseases. In this review, we discuss how mitochondria are involved in modes of cell death, as well as basic research and the latest clinical progress in related fields. We also detail a variety of organ system diseases related to mitochondria, including nervous system diseases, cardiovascular diseases, digestive system diseases, respiratory diseases, endocrine diseases, urinary system diseases and cancer. We highlight the role that mitochondria play in these diseases and suggest possible therapeutic directions as well as pressing issues that need to be addressed today. Because of the key role of mitochondria in cell death, a comprehensive understanding of mitochondria can help provide more effective strategies for clinical treatment. Frontiers Media S.A. 2022-03-07 /pmc/articles/PMC8935059/ /pubmed/35321239 http://dx.doi.org/10.3389/fcell.2022.832356 Text en Copyright © 2022 Tian, Liu, Li, Zhu and Zhao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Tian, Chuwen
Liu, Yifan
Li, Zhuoshu
Zhu, Ping
Zhao, Mingyi
Mitochondria Related Cell Death Modalities and Disease
title Mitochondria Related Cell Death Modalities and Disease
title_full Mitochondria Related Cell Death Modalities and Disease
title_fullStr Mitochondria Related Cell Death Modalities and Disease
title_full_unstemmed Mitochondria Related Cell Death Modalities and Disease
title_short Mitochondria Related Cell Death Modalities and Disease
title_sort mitochondria related cell death modalities and disease
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8935059/
https://www.ncbi.nlm.nih.gov/pubmed/35321239
http://dx.doi.org/10.3389/fcell.2022.832356
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