Cargando…
Regulation of CD38 on Multiple Myeloma and NK Cells by Monoclonal Antibodies
CD38 is highly expressed on multiple myeloma (MM) cells and plays a role in regulating tumor generation and development. CD38 monoclonal antibodies (mAbs) have been used as an effective therapy for MM treatment by various mechanisms, including complement-dependent cytotoxic effects, antibody-depende...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8935232/ https://www.ncbi.nlm.nih.gov/pubmed/35342342 http://dx.doi.org/10.7150/ijbs.68148 |
_version_ | 1784672003209297920 |
---|---|
author | Wu, Hao-Tian Zhao, Xiang-Yu |
author_facet | Wu, Hao-Tian Zhao, Xiang-Yu |
author_sort | Wu, Hao-Tian |
collection | PubMed |
description | CD38 is highly expressed on multiple myeloma (MM) cells and plays a role in regulating tumor generation and development. CD38 monoclonal antibodies (mAbs) have been used as an effective therapy for MM treatment by various mechanisms, including complement-dependent cytotoxic effects, antibody-dependent cell-mediated cytotoxicity, antibody-dependent cellular phagocytosis, programmed cell death, enzymatic modulation, and immunomodulation. Although CD38 mAbs inhibit the proliferation and survival of MM cells, there are substantial side effects on antitumoral NK cells. The NK-mediated immune response needs to be further evaluated to minimize the adverse effects of NK cell loss. The killing effect of CD38 mAbs on CD38(high) NK cells should be minimized and the potential combination of CD38(low/-) NK cells and CD38 mAbs should be maximized to better benefit from their therapeutic efficacy against MM. CD38 mAb effects against MM can be maximized by combination therapies with immunomodulatory imide drugs (IMiDs), proteasome inhibitors (PIs), anti-programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) antibodies, or cellular therapies for the treatment of MM, especially in patients with relapsed or refractory MM (R/R MM) and drug-resistant MM. |
format | Online Article Text |
id | pubmed-8935232 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-89352322022-03-24 Regulation of CD38 on Multiple Myeloma and NK Cells by Monoclonal Antibodies Wu, Hao-Tian Zhao, Xiang-Yu Int J Biol Sci Review CD38 is highly expressed on multiple myeloma (MM) cells and plays a role in regulating tumor generation and development. CD38 monoclonal antibodies (mAbs) have been used as an effective therapy for MM treatment by various mechanisms, including complement-dependent cytotoxic effects, antibody-dependent cell-mediated cytotoxicity, antibody-dependent cellular phagocytosis, programmed cell death, enzymatic modulation, and immunomodulation. Although CD38 mAbs inhibit the proliferation and survival of MM cells, there are substantial side effects on antitumoral NK cells. The NK-mediated immune response needs to be further evaluated to minimize the adverse effects of NK cell loss. The killing effect of CD38 mAbs on CD38(high) NK cells should be minimized and the potential combination of CD38(low/-) NK cells and CD38 mAbs should be maximized to better benefit from their therapeutic efficacy against MM. CD38 mAb effects against MM can be maximized by combination therapies with immunomodulatory imide drugs (IMiDs), proteasome inhibitors (PIs), anti-programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) antibodies, or cellular therapies for the treatment of MM, especially in patients with relapsed or refractory MM (R/R MM) and drug-resistant MM. Ivyspring International Publisher 2022-02-21 /pmc/articles/PMC8935232/ /pubmed/35342342 http://dx.doi.org/10.7150/ijbs.68148 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Review Wu, Hao-Tian Zhao, Xiang-Yu Regulation of CD38 on Multiple Myeloma and NK Cells by Monoclonal Antibodies |
title | Regulation of CD38 on Multiple Myeloma and NK Cells by Monoclonal Antibodies |
title_full | Regulation of CD38 on Multiple Myeloma and NK Cells by Monoclonal Antibodies |
title_fullStr | Regulation of CD38 on Multiple Myeloma and NK Cells by Monoclonal Antibodies |
title_full_unstemmed | Regulation of CD38 on Multiple Myeloma and NK Cells by Monoclonal Antibodies |
title_short | Regulation of CD38 on Multiple Myeloma and NK Cells by Monoclonal Antibodies |
title_sort | regulation of cd38 on multiple myeloma and nk cells by monoclonal antibodies |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8935232/ https://www.ncbi.nlm.nih.gov/pubmed/35342342 http://dx.doi.org/10.7150/ijbs.68148 |
work_keys_str_mv | AT wuhaotian regulationofcd38onmultiplemyelomaandnkcellsbymonoclonalantibodies AT zhaoxiangyu regulationofcd38onmultiplemyelomaandnkcellsbymonoclonalantibodies |