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No evidence that herpes zoster is associated with increased risk of dementia diagnosis

OBJECTIVE: To investigate whether herpes zoster (HZ) was associated with subsequent increased risk of dementia diagnosis. METHODS: We conducted a historical cohort study using primary care electronic health records from the Clinical Practice Research Datalink in the United Kingdom. Individuals with...

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Autores principales: Warren‐Gash, Charlotte, Williamson, Elizabeth, Shiekh, Suhail I., Borjas‐Howard, James, Pearce, Neil, Breuer, Judith M., Smeeth, Liam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8935278/
https://www.ncbi.nlm.nih.gov/pubmed/35170873
http://dx.doi.org/10.1002/acn3.51525
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author Warren‐Gash, Charlotte
Williamson, Elizabeth
Shiekh, Suhail I.
Borjas‐Howard, James
Pearce, Neil
Breuer, Judith M.
Smeeth, Liam
author_facet Warren‐Gash, Charlotte
Williamson, Elizabeth
Shiekh, Suhail I.
Borjas‐Howard, James
Pearce, Neil
Breuer, Judith M.
Smeeth, Liam
author_sort Warren‐Gash, Charlotte
collection PubMed
description OBJECTIVE: To investigate whether herpes zoster (HZ) was associated with subsequent increased risk of dementia diagnosis. METHODS: We conducted a historical cohort study using primary care electronic health records from the Clinical Practice Research Datalink in the United Kingdom. Individuals with incident HZ aged ≥40 years from 2000 to 2017 were matched with up to four individuals without HZ by age, sex, primary care practise and calendar time. The primary outcome was a new diagnosis of all‐cause dementia. We used the Cox proportional hazards regression adjusting for demographic, lifestyle and clinical confounders to assess any association between HZ and dementia. We investigated interactions with sex, frailty index and antiviral treatment and conducted various sensitivity analyses. RESULTS: The cohort comprised 177,144 individuals with HZ and 706,901 matched unexposed individuals (median age 65 years (IQR 55.1–75.0), 40% male) followed for a median duration of 4.6 years (IQR 2.0–8.1). In total, 26,585 (3%) patients had an incident dementia diagnosis recorded and 113,056 patients died (12.8%). HZ was associated with a small reduction in dementia diagnosis (adjusted HR 0.92 (95% CI 0.89–0.95)), occurring predominantly in frail individuals and females. For patients who were fit (578,115, 65%), no association was seen (adjusted HR 0.97, 95% CI 0.92–1.02). There was no association between HZ and a composite outcome of dementia or death (adjusted HR 1.00, 95% CI 0.99–1.02). Dementia risk did not vary by prescription of antiviral agents. Sensitivity analyses showed consistent results. INTERPRETATION: HZ was not associated with increased dementia diagnosis in a UK primary care‐based cohort.
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spelling pubmed-89352782022-03-24 No evidence that herpes zoster is associated with increased risk of dementia diagnosis Warren‐Gash, Charlotte Williamson, Elizabeth Shiekh, Suhail I. Borjas‐Howard, James Pearce, Neil Breuer, Judith M. Smeeth, Liam Ann Clin Transl Neurol Research Articles OBJECTIVE: To investigate whether herpes zoster (HZ) was associated with subsequent increased risk of dementia diagnosis. METHODS: We conducted a historical cohort study using primary care electronic health records from the Clinical Practice Research Datalink in the United Kingdom. Individuals with incident HZ aged ≥40 years from 2000 to 2017 were matched with up to four individuals without HZ by age, sex, primary care practise and calendar time. The primary outcome was a new diagnosis of all‐cause dementia. We used the Cox proportional hazards regression adjusting for demographic, lifestyle and clinical confounders to assess any association between HZ and dementia. We investigated interactions with sex, frailty index and antiviral treatment and conducted various sensitivity analyses. RESULTS: The cohort comprised 177,144 individuals with HZ and 706,901 matched unexposed individuals (median age 65 years (IQR 55.1–75.0), 40% male) followed for a median duration of 4.6 years (IQR 2.0–8.1). In total, 26,585 (3%) patients had an incident dementia diagnosis recorded and 113,056 patients died (12.8%). HZ was associated with a small reduction in dementia diagnosis (adjusted HR 0.92 (95% CI 0.89–0.95)), occurring predominantly in frail individuals and females. For patients who were fit (578,115, 65%), no association was seen (adjusted HR 0.97, 95% CI 0.92–1.02). There was no association between HZ and a composite outcome of dementia or death (adjusted HR 1.00, 95% CI 0.99–1.02). Dementia risk did not vary by prescription of antiviral agents. Sensitivity analyses showed consistent results. INTERPRETATION: HZ was not associated with increased dementia diagnosis in a UK primary care‐based cohort. John Wiley and Sons Inc. 2022-02-16 /pmc/articles/PMC8935278/ /pubmed/35170873 http://dx.doi.org/10.1002/acn3.51525 Text en © 2022 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Warren‐Gash, Charlotte
Williamson, Elizabeth
Shiekh, Suhail I.
Borjas‐Howard, James
Pearce, Neil
Breuer, Judith M.
Smeeth, Liam
No evidence that herpes zoster is associated with increased risk of dementia diagnosis
title No evidence that herpes zoster is associated with increased risk of dementia diagnosis
title_full No evidence that herpes zoster is associated with increased risk of dementia diagnosis
title_fullStr No evidence that herpes zoster is associated with increased risk of dementia diagnosis
title_full_unstemmed No evidence that herpes zoster is associated with increased risk of dementia diagnosis
title_short No evidence that herpes zoster is associated with increased risk of dementia diagnosis
title_sort no evidence that herpes zoster is associated with increased risk of dementia diagnosis
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8935278/
https://www.ncbi.nlm.nih.gov/pubmed/35170873
http://dx.doi.org/10.1002/acn3.51525
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