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The histological type of endometrial cancer is not associated with menopause status at diagnosis
The latest evidence suggests that type 2 endometrial cancer may not be completely oestrogen-independent, indicating that the status of hormonal change may not be associated with the traditional classification of endometrial cancer, including the histological subtypes. However, this has not been inve...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8935384/ https://www.ncbi.nlm.nih.gov/pubmed/35237786 http://dx.doi.org/10.1042/BSR20212192 |
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author | Sun, Xinyi Zhang, Yi Shen, Fang Liu, Yang Chen, George Qiaoqi Zhao, Min Chen, Qi |
author_facet | Sun, Xinyi Zhang, Yi Shen, Fang Liu, Yang Chen, George Qiaoqi Zhao, Min Chen, Qi |
author_sort | Sun, Xinyi |
collection | PubMed |
description | The latest evidence suggests that type 2 endometrial cancer may not be completely oestrogen-independent, indicating that the status of hormonal change may not be associated with the traditional classification of endometrial cancer, including the histological subtypes. However, this has not been investigated. Menopause is commonly considered a state of hormonal change in women. In the present study, we investigated the association of menopause with the histological types of endometrial cancer. Data on the histological type, menopause status at diagnosis, age at diagnosis, parity, body mass index (BMI), and overall survival rate from 2122 cases were collected. The difference in risk in developing type 1 or type 2 endometrial cancer between premenopausal and postmenopausal patients was 5.457%. A statistical difference in the association of menopause with the histological types between the two groups was seen in endometrioid and serous carcinoma, with a risk difference of 5.6 or 3.8%. A statistical difference in the association of menopause with parity between the groups was only seen in endometrioid and adenosquamous carcinoma, with a risk difference of 7.1 or 3.7%. However, BMI was not associated with histological type and the overall survival rate was not associated with menopause (P=0.764). We reported a relatively small difference in the association of menopause with type 1 or type 2, or the histological types of endometrial cancer. The survival rate was not associated with menopause. Our study suggests that menopause status at diagnosis was not strongly associated with the histological subtypes of endometrial cancer. |
format | Online Article Text |
id | pubmed-8935384 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89353842022-03-21 The histological type of endometrial cancer is not associated with menopause status at diagnosis Sun, Xinyi Zhang, Yi Shen, Fang Liu, Yang Chen, George Qiaoqi Zhao, Min Chen, Qi Biosci Rep Cancer The latest evidence suggests that type 2 endometrial cancer may not be completely oestrogen-independent, indicating that the status of hormonal change may not be associated with the traditional classification of endometrial cancer, including the histological subtypes. However, this has not been investigated. Menopause is commonly considered a state of hormonal change in women. In the present study, we investigated the association of menopause with the histological types of endometrial cancer. Data on the histological type, menopause status at diagnosis, age at diagnosis, parity, body mass index (BMI), and overall survival rate from 2122 cases were collected. The difference in risk in developing type 1 or type 2 endometrial cancer between premenopausal and postmenopausal patients was 5.457%. A statistical difference in the association of menopause with the histological types between the two groups was seen in endometrioid and serous carcinoma, with a risk difference of 5.6 or 3.8%. A statistical difference in the association of menopause with parity between the groups was only seen in endometrioid and adenosquamous carcinoma, with a risk difference of 7.1 or 3.7%. However, BMI was not associated with histological type and the overall survival rate was not associated with menopause (P=0.764). We reported a relatively small difference in the association of menopause with type 1 or type 2, or the histological types of endometrial cancer. The survival rate was not associated with menopause. Our study suggests that menopause status at diagnosis was not strongly associated with the histological subtypes of endometrial cancer. Portland Press Ltd. 2022-03-16 /pmc/articles/PMC8935384/ /pubmed/35237786 http://dx.doi.org/10.1042/BSR20212192 Text en © 2022 The Author(s). https://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) . Open access for this article was enabled by the participation of The University of Auckland in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with CAUL. |
spellingShingle | Cancer Sun, Xinyi Zhang, Yi Shen, Fang Liu, Yang Chen, George Qiaoqi Zhao, Min Chen, Qi The histological type of endometrial cancer is not associated with menopause status at diagnosis |
title | The histological type of endometrial cancer is not associated with menopause status at diagnosis |
title_full | The histological type of endometrial cancer is not associated with menopause status at diagnosis |
title_fullStr | The histological type of endometrial cancer is not associated with menopause status at diagnosis |
title_full_unstemmed | The histological type of endometrial cancer is not associated with menopause status at diagnosis |
title_short | The histological type of endometrial cancer is not associated with menopause status at diagnosis |
title_sort | histological type of endometrial cancer is not associated with menopause status at diagnosis |
topic | Cancer |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8935384/ https://www.ncbi.nlm.nih.gov/pubmed/35237786 http://dx.doi.org/10.1042/BSR20212192 |
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