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Targeting ASCT2-mediated glutamine metabolism inhibits proliferation and promotes apoptosis of pancreatic cancer cells

Some tumor cells have a high rate of glutamine uptake and exhibit glutamine addiction. Alanine-serine cysteine-preferring transporter 2 (ASCT2) is a major mediator of glutamine supply in many tumor cells, but the underlying effects and mechanisms of ASCT2 in pancreatic cancer (PC) are largely unknow...

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Detalles Bibliográficos
Autores principales:	Wang, Wenbin, Pan, Haihua, Ren, Feihua, Chen, Hongxia, Ren, Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2022
Materias:	Biotechnology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8935385/ https://www.ncbi.nlm.nih.gov/pubmed/35237783 http://dx.doi.org/10.1042/BSR20212171

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