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Cerbellar medulloblastoma in the elderly: Case report and review of the literature
INTRODUCTION: Medulloblastoma is a malignant tumor of the posterior fossa which is mainly found in children aged less than 15 years of age. This tumor is uncommon in adults, especially those above 40 years old. We report the very rare case of a 61 years-old woman who was diagnosed with a cerebellar...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8935497/ https://www.ncbi.nlm.nih.gov/pubmed/35313184 http://dx.doi.org/10.1016/j.ijscr.2022.106949 |
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author | Gader, Ghassen Badri, Mohamed Guediche, Skander Rkhami, Mouna Zammel, Ihsèn |
author_facet | Gader, Ghassen Badri, Mohamed Guediche, Skander Rkhami, Mouna Zammel, Ihsèn |
author_sort | Gader, Ghassen |
collection | PubMed |
description | INTRODUCTION: Medulloblastoma is a malignant tumor of the posterior fossa which is mainly found in children aged less than 15 years of age. This tumor is uncommon in adults, especially those above 40 years old. We report the very rare case of a 61 years-old woman who was diagnosed with a cerebellar medulloblastoma. CASE PRESENTATION: We present a case of a 61-year-old woman who presented for signs of elevated intracranial and cerebellar syndrome related to an atypical mass located within the left cerebellar hemisphere. The patient underwent an incomplete resection of the mass due to the infiltration of the superior cerebellar peduncle. Histology and immunohistochemistry concluded to a classic medulloblastoma. Thus, she underwent postoperative radiotherapy. DISCUSSION: Medulloblastoma is very rarely diagnosed in patients above 60 years, as only 14 cases have already been published. Therapeutic approach is based on surgery and radiotherapy in both children and adults, whereas addition of chemotherapy is controversial. CONCLUSIONS: Even in adults over 60 years of age, medulloblastoma should be included in the differential diagnosis of a cerebellar mass. This diagnosis should be kept in mind as clinical and radiological present specificities to the features commonly described in infants' medulloblastoma. |
format | Online Article Text |
id | pubmed-8935497 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-89354972022-03-22 Cerbellar medulloblastoma in the elderly: Case report and review of the literature Gader, Ghassen Badri, Mohamed Guediche, Skander Rkhami, Mouna Zammel, Ihsèn Int J Surg Case Rep Case Report INTRODUCTION: Medulloblastoma is a malignant tumor of the posterior fossa which is mainly found in children aged less than 15 years of age. This tumor is uncommon in adults, especially those above 40 years old. We report the very rare case of a 61 years-old woman who was diagnosed with a cerebellar medulloblastoma. CASE PRESENTATION: We present a case of a 61-year-old woman who presented for signs of elevated intracranial and cerebellar syndrome related to an atypical mass located within the left cerebellar hemisphere. The patient underwent an incomplete resection of the mass due to the infiltration of the superior cerebellar peduncle. Histology and immunohistochemistry concluded to a classic medulloblastoma. Thus, she underwent postoperative radiotherapy. DISCUSSION: Medulloblastoma is very rarely diagnosed in patients above 60 years, as only 14 cases have already been published. Therapeutic approach is based on surgery and radiotherapy in both children and adults, whereas addition of chemotherapy is controversial. CONCLUSIONS: Even in adults over 60 years of age, medulloblastoma should be included in the differential diagnosis of a cerebellar mass. This diagnosis should be kept in mind as clinical and radiological present specificities to the features commonly described in infants' medulloblastoma. Elsevier 2022-03-16 /pmc/articles/PMC8935497/ /pubmed/35313184 http://dx.doi.org/10.1016/j.ijscr.2022.106949 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Gader, Ghassen Badri, Mohamed Guediche, Skander Rkhami, Mouna Zammel, Ihsèn Cerbellar medulloblastoma in the elderly: Case report and review of the literature |
title | Cerbellar medulloblastoma in the elderly: Case report and review of the literature |
title_full | Cerbellar medulloblastoma in the elderly: Case report and review of the literature |
title_fullStr | Cerbellar medulloblastoma in the elderly: Case report and review of the literature |
title_full_unstemmed | Cerbellar medulloblastoma in the elderly: Case report and review of the literature |
title_short | Cerbellar medulloblastoma in the elderly: Case report and review of the literature |
title_sort | cerbellar medulloblastoma in the elderly: case report and review of the literature |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8935497/ https://www.ncbi.nlm.nih.gov/pubmed/35313184 http://dx.doi.org/10.1016/j.ijscr.2022.106949 |
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