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Cerbellar medulloblastoma in the elderly: Case report and review of the literature

INTRODUCTION: Medulloblastoma is a malignant tumor of the posterior fossa which is mainly found in children aged less than 15 years of age. This tumor is uncommon in adults, especially those above 40 years old. We report the very rare case of a 61 years-old woman who was diagnosed with a cerebellar...

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Autores principales: Gader, Ghassen, Badri, Mohamed, Guediche, Skander, Rkhami, Mouna, Zammel, Ihsèn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8935497/
https://www.ncbi.nlm.nih.gov/pubmed/35313184
http://dx.doi.org/10.1016/j.ijscr.2022.106949
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author Gader, Ghassen
Badri, Mohamed
Guediche, Skander
Rkhami, Mouna
Zammel, Ihsèn
author_facet Gader, Ghassen
Badri, Mohamed
Guediche, Skander
Rkhami, Mouna
Zammel, Ihsèn
author_sort Gader, Ghassen
collection PubMed
description INTRODUCTION: Medulloblastoma is a malignant tumor of the posterior fossa which is mainly found in children aged less than 15 years of age. This tumor is uncommon in adults, especially those above 40 years old. We report the very rare case of a 61 years-old woman who was diagnosed with a cerebellar medulloblastoma. CASE PRESENTATION: We present a case of a 61-year-old woman who presented for signs of elevated intracranial and cerebellar syndrome related to an atypical mass located within the left cerebellar hemisphere. The patient underwent an incomplete resection of the mass due to the infiltration of the superior cerebellar peduncle. Histology and immunohistochemistry concluded to a classic medulloblastoma. Thus, she underwent postoperative radiotherapy. DISCUSSION: Medulloblastoma is very rarely diagnosed in patients above 60 years, as only 14 cases have already been published. Therapeutic approach is based on surgery and radiotherapy in both children and adults, whereas addition of chemotherapy is controversial. CONCLUSIONS: Even in adults over 60 years of age, medulloblastoma should be included in the differential diagnosis of a cerebellar mass. This diagnosis should be kept in mind as clinical and radiological present specificities to the features commonly described in infants' medulloblastoma.
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spelling pubmed-89354972022-03-22 Cerbellar medulloblastoma in the elderly: Case report and review of the literature Gader, Ghassen Badri, Mohamed Guediche, Skander Rkhami, Mouna Zammel, Ihsèn Int J Surg Case Rep Case Report INTRODUCTION: Medulloblastoma is a malignant tumor of the posterior fossa which is mainly found in children aged less than 15 years of age. This tumor is uncommon in adults, especially those above 40 years old. We report the very rare case of a 61 years-old woman who was diagnosed with a cerebellar medulloblastoma. CASE PRESENTATION: We present a case of a 61-year-old woman who presented for signs of elevated intracranial and cerebellar syndrome related to an atypical mass located within the left cerebellar hemisphere. The patient underwent an incomplete resection of the mass due to the infiltration of the superior cerebellar peduncle. Histology and immunohistochemistry concluded to a classic medulloblastoma. Thus, she underwent postoperative radiotherapy. DISCUSSION: Medulloblastoma is very rarely diagnosed in patients above 60 years, as only 14 cases have already been published. Therapeutic approach is based on surgery and radiotherapy in both children and adults, whereas addition of chemotherapy is controversial. CONCLUSIONS: Even in adults over 60 years of age, medulloblastoma should be included in the differential diagnosis of a cerebellar mass. This diagnosis should be kept in mind as clinical and radiological present specificities to the features commonly described in infants' medulloblastoma. Elsevier 2022-03-16 /pmc/articles/PMC8935497/ /pubmed/35313184 http://dx.doi.org/10.1016/j.ijscr.2022.106949 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Gader, Ghassen
Badri, Mohamed
Guediche, Skander
Rkhami, Mouna
Zammel, Ihsèn
Cerbellar medulloblastoma in the elderly: Case report and review of the literature
title Cerbellar medulloblastoma in the elderly: Case report and review of the literature
title_full Cerbellar medulloblastoma in the elderly: Case report and review of the literature
title_fullStr Cerbellar medulloblastoma in the elderly: Case report and review of the literature
title_full_unstemmed Cerbellar medulloblastoma in the elderly: Case report and review of the literature
title_short Cerbellar medulloblastoma in the elderly: Case report and review of the literature
title_sort cerbellar medulloblastoma in the elderly: case report and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8935497/
https://www.ncbi.nlm.nih.gov/pubmed/35313184
http://dx.doi.org/10.1016/j.ijscr.2022.106949
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