Unilateral isolated optic nerve infiltration combined with central retinal artery occlusion in a patient with acute myeloid leukemia

PURPOSE: To report a case of unilateral isolated optic nerve infiltration combined with central retinal artery occlusion in a patient with acute myeloid leukemia. OBSERVATIONS: A 28-year-old acute myeloid leukemia patient with systemic remission after hematopoietic stem cell transplantation presente...

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Autores principales: Zhao, Chen, Wei, Duo, Shi, Xuan, Zhao, Mingwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8935524/
https://www.ncbi.nlm.nih.gov/pubmed/35321253
http://dx.doi.org/10.1016/j.ajoc.2022.101493
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author Zhao, Chen
Wei, Duo
Shi, Xuan
Zhao, Mingwei
author_facet Zhao, Chen
Wei, Duo
Shi, Xuan
Zhao, Mingwei
author_sort Zhao, Chen
collection PubMed
description PURPOSE: To report a case of unilateral isolated optic nerve infiltration combined with central retinal artery occlusion in a patient with acute myeloid leukemia. OBSERVATIONS: A 28-year-old acute myeloid leukemia patient with systemic remission after hematopoietic stem cell transplantation presented with optic nerve infiltration combined with central retinal artery occlusion. Fundus examination showed diffuse papillary swelling with blurred margins and whitening macular with cherry-red spot. CBFβ-MYH11 fusion transcript analysis revealed central nervous system relapse of acute myeloid leukemia and optic nerve infiltration. CONCLUSIONS AND IMPORTANCE: Isolated optic nerve infiltration combined with central retinal artery occlusion is an extremely rare presentation in acute myeloid leukemia. Even in the absence of cytological and radiographic evidence from cerebrospinal fluid, optic nerve infiltration should not be ignored.
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spelling pubmed-89355242022-03-22 Unilateral isolated optic nerve infiltration combined with central retinal artery occlusion in a patient with acute myeloid leukemia Zhao, Chen Wei, Duo Shi, Xuan Zhao, Mingwei Am J Ophthalmol Case Rep Case Report PURPOSE: To report a case of unilateral isolated optic nerve infiltration combined with central retinal artery occlusion in a patient with acute myeloid leukemia. OBSERVATIONS: A 28-year-old acute myeloid leukemia patient with systemic remission after hematopoietic stem cell transplantation presented with optic nerve infiltration combined with central retinal artery occlusion. Fundus examination showed diffuse papillary swelling with blurred margins and whitening macular with cherry-red spot. CBFβ-MYH11 fusion transcript analysis revealed central nervous system relapse of acute myeloid leukemia and optic nerve infiltration. CONCLUSIONS AND IMPORTANCE: Isolated optic nerve infiltration combined with central retinal artery occlusion is an extremely rare presentation in acute myeloid leukemia. Even in the absence of cytological and radiographic evidence from cerebrospinal fluid, optic nerve infiltration should not be ignored. Elsevier 2022-03-16 /pmc/articles/PMC8935524/ /pubmed/35321253 http://dx.doi.org/10.1016/j.ajoc.2022.101493 Text en © 2022 Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Zhao, Chen
Wei, Duo
Shi, Xuan
Zhao, Mingwei
Unilateral isolated optic nerve infiltration combined with central retinal artery occlusion in a patient with acute myeloid leukemia
title Unilateral isolated optic nerve infiltration combined with central retinal artery occlusion in a patient with acute myeloid leukemia
title_full Unilateral isolated optic nerve infiltration combined with central retinal artery occlusion in a patient with acute myeloid leukemia
title_fullStr Unilateral isolated optic nerve infiltration combined with central retinal artery occlusion in a patient with acute myeloid leukemia
title_full_unstemmed Unilateral isolated optic nerve infiltration combined with central retinal artery occlusion in a patient with acute myeloid leukemia
title_short Unilateral isolated optic nerve infiltration combined with central retinal artery occlusion in a patient with acute myeloid leukemia
title_sort unilateral isolated optic nerve infiltration combined with central retinal artery occlusion in a patient with acute myeloid leukemia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8935524/
https://www.ncbi.nlm.nih.gov/pubmed/35321253
http://dx.doi.org/10.1016/j.ajoc.2022.101493
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