Influence of probenecid on endoxifen systemic exposure in breast cancer patients on adjuvant tamoxifen treatment

INTRODUCTION: In breast cancer patients treated with the anti-estrogen tamoxifen, low concentrations of the active metabolite endoxifen are associated with more disease recurrence. We hypothesized that we could increase endoxifen concentrations by induction of its formation and inhibition of its met...

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Detalles Bibliográficos
Autores principales: Buck, Stefan A. J., Braal, C. Louwrens, Hofman, Maaike M., Oomen-de Hoop, Esther, de Bruijn, Peter, Ghobadi Moghaddam-Helmantel, Inge M., Hussaarts, Koen G. A. M., Vastbinder, Mijntje B., van Rossum-Schornagel, Quirine C., van Schaik, Ron H. N., Jager, Agnes, Koolen, Stijn L. W., Mathijssen, Ron H. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8935557/
https://www.ncbi.nlm.nih.gov/pubmed/35321309
http://dx.doi.org/10.1177/17588359221081075

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