The secretion profile of mesenchymal stem cells and potential applications in treating human diseases

Mesenchymal stromal/stem cells (MSCs) possess multi-lineage differentiation and self-renewal potentials. MSCs-based therapies have been widely utilized for the treatment of diverse inflammatory diseases, due to the potent immunoregulatory functions of MSCs. An increasing body of evidence indicates t...

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Autores principales: Han, Yuyi, Yang, Jianxin, Fang, Jiankai, Zhou, Yipeng, Candi, Eleonora, Wang, Jihong, Hua, Dong, Shao, Changshun, Shi, Yufang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8935608/
https://www.ncbi.nlm.nih.gov/pubmed/35314676
http://dx.doi.org/10.1038/s41392-022-00932-0
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author Han, Yuyi
Yang, Jianxin
Fang, Jiankai
Zhou, Yipeng
Candi, Eleonora
Wang, Jihong
Hua, Dong
Shao, Changshun
Shi, Yufang
author_facet Han, Yuyi
Yang, Jianxin
Fang, Jiankai
Zhou, Yipeng
Candi, Eleonora
Wang, Jihong
Hua, Dong
Shao, Changshun
Shi, Yufang
author_sort Han, Yuyi
collection PubMed
description Mesenchymal stromal/stem cells (MSCs) possess multi-lineage differentiation and self-renewal potentials. MSCs-based therapies have been widely utilized for the treatment of diverse inflammatory diseases, due to the potent immunoregulatory functions of MSCs. An increasing body of evidence indicates that MSCs exert their therapeutic effects largely through their paracrine actions. Growth factors, cytokines, chemokines, extracellular matrix components, and metabolic products were all found to be functional molecules of MSCs in various therapeutic paradigms. These secretory factors contribute to immune modulation, tissue remodeling, and cellular homeostasis during regeneration. In this review, we summarize and discuss recent advances in our understanding of the secretory behavior of MSCs and the intracellular communication that accounts for their potential in treating human diseases.
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spelling pubmed-89356082022-03-21 The secretion profile of mesenchymal stem cells and potential applications in treating human diseases Han, Yuyi Yang, Jianxin Fang, Jiankai Zhou, Yipeng Candi, Eleonora Wang, Jihong Hua, Dong Shao, Changshun Shi, Yufang Signal Transduct Target Ther Review Article Mesenchymal stromal/stem cells (MSCs) possess multi-lineage differentiation and self-renewal potentials. MSCs-based therapies have been widely utilized for the treatment of diverse inflammatory diseases, due to the potent immunoregulatory functions of MSCs. An increasing body of evidence indicates that MSCs exert their therapeutic effects largely through their paracrine actions. Growth factors, cytokines, chemokines, extracellular matrix components, and metabolic products were all found to be functional molecules of MSCs in various therapeutic paradigms. These secretory factors contribute to immune modulation, tissue remodeling, and cellular homeostasis during regeneration. In this review, we summarize and discuss recent advances in our understanding of the secretory behavior of MSCs and the intracellular communication that accounts for their potential in treating human diseases. Nature Publishing Group UK 2022-03-21 /pmc/articles/PMC8935608/ /pubmed/35314676 http://dx.doi.org/10.1038/s41392-022-00932-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Han, Yuyi
Yang, Jianxin
Fang, Jiankai
Zhou, Yipeng
Candi, Eleonora
Wang, Jihong
Hua, Dong
Shao, Changshun
Shi, Yufang
The secretion profile of mesenchymal stem cells and potential applications in treating human diseases
title The secretion profile of mesenchymal stem cells and potential applications in treating human diseases
title_full The secretion profile of mesenchymal stem cells and potential applications in treating human diseases
title_fullStr The secretion profile of mesenchymal stem cells and potential applications in treating human diseases
title_full_unstemmed The secretion profile of mesenchymal stem cells and potential applications in treating human diseases
title_short The secretion profile of mesenchymal stem cells and potential applications in treating human diseases
title_sort secretion profile of mesenchymal stem cells and potential applications in treating human diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8935608/
https://www.ncbi.nlm.nih.gov/pubmed/35314676
http://dx.doi.org/10.1038/s41392-022-00932-0
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