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Incidental pineal gland cyst in girls with early onset of puberty

BACKGROUND: The causes of an early onset of puberty are still not clearly defined and may vary from subject to subject. In girls, even if 90% of early puberty is idiopathic, magnetic resonance imaging (MRI) of the brain is performed to exclude secondary causes of precocious puberty, in particular pa...

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Autores principales: Filippo, Gianpaolo De, Gaudino, Rossella, Calcaterra, Valeria, Villani, Alberto, Bozzola, Elena, Bozzola, Mauro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8935686/
https://www.ncbi.nlm.nih.gov/pubmed/35313951
http://dx.doi.org/10.1186/s13052-022-01235-4
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author Filippo, Gianpaolo De
Gaudino, Rossella
Calcaterra, Valeria
Villani, Alberto
Bozzola, Elena
Bozzola, Mauro
author_facet Filippo, Gianpaolo De
Gaudino, Rossella
Calcaterra, Valeria
Villani, Alberto
Bozzola, Elena
Bozzola, Mauro
author_sort Filippo, Gianpaolo De
collection PubMed
description BACKGROUND: The causes of an early onset of puberty are still not clearly defined and may vary from subject to subject. In girls, even if 90% of early puberty is idiopathic, magnetic resonance imaging (MRI) of the brain is performed to exclude secondary causes of precocious puberty, in particular pathological lesions as hypothalamic tumours (hamartoma). In some cases, other intracranial lesions are considered as incidental findings. Aim of the study is evaluating the prevalence of abnormal intracranial lesions detected by brain magnetic resonance imaging MRI with particular focus on the prevalence of pineal gland cysts in the diagnostic work-up of girls with central precocious puberty (CPP) as onset before 8 years and central early puberty (CEP) as onset before 10 years. MATERIAL AND METHODS: MRI data of girls referred from January 2010 to December 2015 to the Pediatric Endocrinology Unit of University of Pavia for early onset of breast development were collected. RESULTS: We collected 123 MRI data of girls referred to the Pediatric Endocrinology Unit of University of Pavia for early onset of breast development in the study period. Out of them, 25 (20.3%) had cerebral abnormalities and 15 (12.2%) had pineal gland cysts. No significant differences were noted in auxological, ultrasound and hormonal parameters at diagnosis among girls with or without pineal cysts. Patients have been observed for at least three years after the discontinuation of therapy. None of our patients had an unfavorable evolution. CONCLUSIONS: Although pineal cysts seem to be not involved in the onset of puberty, the relevance of the finding remains controversial. Our study wants to provide further insight into the incidence of pineal cysts in pubertal advances. Of note, pineal cysts are often asymptomatic and do not evolve over time.
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spelling pubmed-89356862022-03-23 Incidental pineal gland cyst in girls with early onset of puberty Filippo, Gianpaolo De Gaudino, Rossella Calcaterra, Valeria Villani, Alberto Bozzola, Elena Bozzola, Mauro Ital J Pediatr Research BACKGROUND: The causes of an early onset of puberty are still not clearly defined and may vary from subject to subject. In girls, even if 90% of early puberty is idiopathic, magnetic resonance imaging (MRI) of the brain is performed to exclude secondary causes of precocious puberty, in particular pathological lesions as hypothalamic tumours (hamartoma). In some cases, other intracranial lesions are considered as incidental findings. Aim of the study is evaluating the prevalence of abnormal intracranial lesions detected by brain magnetic resonance imaging MRI with particular focus on the prevalence of pineal gland cysts in the diagnostic work-up of girls with central precocious puberty (CPP) as onset before 8 years and central early puberty (CEP) as onset before 10 years. MATERIAL AND METHODS: MRI data of girls referred from January 2010 to December 2015 to the Pediatric Endocrinology Unit of University of Pavia for early onset of breast development were collected. RESULTS: We collected 123 MRI data of girls referred to the Pediatric Endocrinology Unit of University of Pavia for early onset of breast development in the study period. Out of them, 25 (20.3%) had cerebral abnormalities and 15 (12.2%) had pineal gland cysts. No significant differences were noted in auxological, ultrasound and hormonal parameters at diagnosis among girls with or without pineal cysts. Patients have been observed for at least three years after the discontinuation of therapy. None of our patients had an unfavorable evolution. CONCLUSIONS: Although pineal cysts seem to be not involved in the onset of puberty, the relevance of the finding remains controversial. Our study wants to provide further insight into the incidence of pineal cysts in pubertal advances. Of note, pineal cysts are often asymptomatic and do not evolve over time. BioMed Central 2022-03-21 /pmc/articles/PMC8935686/ /pubmed/35313951 http://dx.doi.org/10.1186/s13052-022-01235-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Filippo, Gianpaolo De
Gaudino, Rossella
Calcaterra, Valeria
Villani, Alberto
Bozzola, Elena
Bozzola, Mauro
Incidental pineal gland cyst in girls with early onset of puberty
title Incidental pineal gland cyst in girls with early onset of puberty
title_full Incidental pineal gland cyst in girls with early onset of puberty
title_fullStr Incidental pineal gland cyst in girls with early onset of puberty
title_full_unstemmed Incidental pineal gland cyst in girls with early onset of puberty
title_short Incidental pineal gland cyst in girls with early onset of puberty
title_sort incidental pineal gland cyst in girls with early onset of puberty
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8935686/
https://www.ncbi.nlm.nih.gov/pubmed/35313951
http://dx.doi.org/10.1186/s13052-022-01235-4
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