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Evaluation of the association of endometriosis and mammographic breast density, a cross-sectional study

BACKGROUND: Endometriosis is a common benign but painful gynecologic condition. Studies suggest that the risk of some types of malignancies such as breast cancer is higher in women with endometriosis. Mammographic breast density (MBD) is known as an important predictor for breast cancer. The present...

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Autores principales: Moini, Ashraf, Salari, Elnaz, Rashidi, Hadi, Maajani, Khadije, Abedi, Mahboubeh, Bayani, Leila, Alipour, Sadaf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8935711/
https://www.ncbi.nlm.nih.gov/pubmed/35313883
http://dx.doi.org/10.1186/s12905-022-01663-8
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author Moini, Ashraf
Salari, Elnaz
Rashidi, Hadi
Maajani, Khadije
Abedi, Mahboubeh
Bayani, Leila
Alipour, Sadaf
author_facet Moini, Ashraf
Salari, Elnaz
Rashidi, Hadi
Maajani, Khadije
Abedi, Mahboubeh
Bayani, Leila
Alipour, Sadaf
author_sort Moini, Ashraf
collection PubMed
description BACKGROUND: Endometriosis is a common benign but painful gynecologic condition. Studies suggest that the risk of some types of malignancies such as breast cancer is higher in women with endometriosis. Mammographic breast density (MBD) is known as an important predictor for breast cancer. The present study aimed to investigate the potential relationship between endometriosis and MBD. METHODS: This cross-sectional study was conducted on 370 women over 40 years of age. Laparoscopic surgery was carried out for the diagnosis of endometriosis. MBD was classified into four categories according to the ACR BI-RADS classification. Statistical analysis was performed using SPSS software to evaluate the potential association between variables. RESULTS: The mean age of all participants was 47.2 ± 6.4 years, and most participants (76.8%) were premenopausal. Multivariate analysis of the potential predictors of MBD, including age, body mass index, oral contraceptive consumption, progesterone consumption, family history of breast cancer and endometriosis showed that age (P value = 0.002), history of progesterone consumption (P value = 0.004) and endometriosis (P value = 0.006) were independent factors for MBD. CONCLUSION: This study indicated that endometriosis had an inverse association with MBD. Age and history of progesterone use were also independent influential factors for MBD. This finding shows that the positive association between breast cancer and endometriosis is not mediated through MBD.
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spelling pubmed-89357112022-03-23 Evaluation of the association of endometriosis and mammographic breast density, a cross-sectional study Moini, Ashraf Salari, Elnaz Rashidi, Hadi Maajani, Khadije Abedi, Mahboubeh Bayani, Leila Alipour, Sadaf BMC Womens Health Research BACKGROUND: Endometriosis is a common benign but painful gynecologic condition. Studies suggest that the risk of some types of malignancies such as breast cancer is higher in women with endometriosis. Mammographic breast density (MBD) is known as an important predictor for breast cancer. The present study aimed to investigate the potential relationship between endometriosis and MBD. METHODS: This cross-sectional study was conducted on 370 women over 40 years of age. Laparoscopic surgery was carried out for the diagnosis of endometriosis. MBD was classified into four categories according to the ACR BI-RADS classification. Statistical analysis was performed using SPSS software to evaluate the potential association between variables. RESULTS: The mean age of all participants was 47.2 ± 6.4 years, and most participants (76.8%) were premenopausal. Multivariate analysis of the potential predictors of MBD, including age, body mass index, oral contraceptive consumption, progesterone consumption, family history of breast cancer and endometriosis showed that age (P value = 0.002), history of progesterone consumption (P value = 0.004) and endometriosis (P value = 0.006) were independent factors for MBD. CONCLUSION: This study indicated that endometriosis had an inverse association with MBD. Age and history of progesterone use were also independent influential factors for MBD. This finding shows that the positive association between breast cancer and endometriosis is not mediated through MBD. BioMed Central 2022-03-21 /pmc/articles/PMC8935711/ /pubmed/35313883 http://dx.doi.org/10.1186/s12905-022-01663-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Moini, Ashraf
Salari, Elnaz
Rashidi, Hadi
Maajani, Khadije
Abedi, Mahboubeh
Bayani, Leila
Alipour, Sadaf
Evaluation of the association of endometriosis and mammographic breast density, a cross-sectional study
title Evaluation of the association of endometriosis and mammographic breast density, a cross-sectional study
title_full Evaluation of the association of endometriosis and mammographic breast density, a cross-sectional study
title_fullStr Evaluation of the association of endometriosis and mammographic breast density, a cross-sectional study
title_full_unstemmed Evaluation of the association of endometriosis and mammographic breast density, a cross-sectional study
title_short Evaluation of the association of endometriosis and mammographic breast density, a cross-sectional study
title_sort evaluation of the association of endometriosis and mammographic breast density, a cross-sectional study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8935711/
https://www.ncbi.nlm.nih.gov/pubmed/35313883
http://dx.doi.org/10.1186/s12905-022-01663-8
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