Expression and functions of adenylyl cyclases in the CNS

Adenylyl cyclases (ADCYs), by generating second messenger cAMP, play important roles in various cellular processes. Their expression, regulation and functions in the CNS, however, remain largely unknown. In this review, we first introduce the classification and structure of ADCYs, followed by a disc...

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Detalles Bibliográficos
Autores principales: Devasani, Karan, Yao, Yao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8935726/
https://www.ncbi.nlm.nih.gov/pubmed/35307032
http://dx.doi.org/10.1186/s12987-022-00322-2
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author Devasani, Karan
Yao, Yao
author_facet Devasani, Karan
Yao, Yao
author_sort Devasani, Karan
collection PubMed
description Adenylyl cyclases (ADCYs), by generating second messenger cAMP, play important roles in various cellular processes. Their expression, regulation and functions in the CNS, however, remain largely unknown. In this review, we first introduce the classification and structure of ADCYs, followed by a discussion of the regulation of mammalian ADCYs (ADCY1-10). Next, the expression and function of each mammalian ADCY isoform are summarized in a region/cell-specific manner. Furthermore, the effects of GPCR-ADCY signaling on blood–brain barrier (BBB) integrity are reviewed. Last, current challenges and future directions are discussed. We aim to provide a succinct review on ADCYs to foster new research in the future.
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spelling pubmed-89357262022-03-23 Expression and functions of adenylyl cyclases in the CNS Devasani, Karan Yao, Yao Fluids Barriers CNS Review Adenylyl cyclases (ADCYs), by generating second messenger cAMP, play important roles in various cellular processes. Their expression, regulation and functions in the CNS, however, remain largely unknown. In this review, we first introduce the classification and structure of ADCYs, followed by a discussion of the regulation of mammalian ADCYs (ADCY1-10). Next, the expression and function of each mammalian ADCY isoform are summarized in a region/cell-specific manner. Furthermore, the effects of GPCR-ADCY signaling on blood–brain barrier (BBB) integrity are reviewed. Last, current challenges and future directions are discussed. We aim to provide a succinct review on ADCYs to foster new research in the future. BioMed Central 2022-03-20 /pmc/articles/PMC8935726/ /pubmed/35307032 http://dx.doi.org/10.1186/s12987-022-00322-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Devasani, Karan
Yao, Yao
Expression and functions of adenylyl cyclases in the CNS
title Expression and functions of adenylyl cyclases in the CNS
title_full Expression and functions of adenylyl cyclases in the CNS
title_fullStr Expression and functions of adenylyl cyclases in the CNS
title_full_unstemmed Expression and functions of adenylyl cyclases in the CNS
title_short Expression and functions of adenylyl cyclases in the CNS
title_sort expression and functions of adenylyl cyclases in the cns
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8935726/
https://www.ncbi.nlm.nih.gov/pubmed/35307032
http://dx.doi.org/10.1186/s12987-022-00322-2
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