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GATD3A, a mitochondrial deglycase with evolutionary origins from gammaproteobacteria, restricts the formation of advanced glycation end products
BACKGROUND: Functional complexity of the eukaryotic mitochondrial proteome is augmented by independent gene acquisition from bacteria since its endosymbiotic origins. Mammalian homologs of many ancestral mitochondrial proteins have uncharacterized catalytic activities. Recent forward genetic approac...
Autores principales: | Smith, Andrew J., Advani, Jayshree, Brock, Daniel C., Nellissery, Jacob, Gumerson, Jessica, Dong, Lijin, Aravind, L., Kennedy, Breandán, Swaroop, Anand |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8935817/ https://www.ncbi.nlm.nih.gov/pubmed/35307029 http://dx.doi.org/10.1186/s12915-022-01267-6 |
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