Exendin-4 and eldecalcitol synergistically promote osteogenic differentiation of bone marrow mesenchymal stem cells through M2 macrophages polarization via PI3K/AKT pathway

BACKGROUND: The incidence of diabetic osteoporosis is increasing. This article evaluates the effect of combination treatment with the hypoglycemic drug exendin-4 (Ex-4) and the vitamin D analog eldecalcitol (ED-71) on improving diabetic osteoporosis and explores the relevant mechanism of action. MET...

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Detalles Bibliográficos
Autores principales: Lu, Yupu, Liu, Shanshan, Yang, Panpan, Kou, Yuying, Li, Congshan, Liu, Hongrui, Li, Minqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8935829/
https://www.ncbi.nlm.nih.gov/pubmed/35313964
http://dx.doi.org/10.1186/s13287-022-02800-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8935829/
https://www.ncbi.nlm.nih.gov/pubmed/35313964
http://dx.doi.org/10.1186/s13287-022-02800-8

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