Targeting an evolutionarily conserved “E-L-L” motif in the spike protein to develop a small molecule fusion inhibitor against SARS-CoV-2

As newer variants of SARS-CoV-2 continue to pose major threats to global human health and economy, identifying novel druggable antiviral targets is the key towards sustenance. Here, we identify an evolutionary conserved “E-L-L” motif present within the HR2 domain of all human and non-human coronavir...

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Detalles Bibliográficos
Autores principales: Jana, Indrani Das, Bhattacharya, Prabuddha, Mayilsamy, Karthick, Banerjee, Saptarshi, Bhattacharje, Gourab, Das, Sayan, Aditya, Seemanti, Ghosh, Anandita, McGill, Andrew R., Srikrishnan, Syamanthak, Das, Amit Kumar, Basak, Amit, Mohapatra, Shyam S., Chandran, Bala, Bhimsaria, Devesh, Mohapatra, Subhra, Roy, Arunava, Mondal, Arindam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8936095/
https://www.ncbi.nlm.nih.gov/pubmed/35313575
http://dx.doi.org/10.1101/2022.03.16.484554

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