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Regulation of Smoothened Trafficking and Abundance in Hedgehog Signaling

The GPCR-family protein Smoothened (Smo) is essential for Hedgehog (Hh) signal transduction in both insects and vertebrates. The regulation of subcellular localization and abundance of Smo is a critical step in Hh signaling. Recent studies have demonstrated that Smo is subjected to ubiquitination me...

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Detalles Bibliográficos
Autores principales: Jia, Jianhang, Jiang, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8936432/
https://www.ncbi.nlm.nih.gov/pubmed/35321245
http://dx.doi.org/10.3389/fcell.2022.847844

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