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Suppressive Effect of Autocrine FGF21 on Autophagy-Deficient Hepatic Tumorigenesis
Mice with hepatocyte-specific deletion of autophagy-related 7 (Atg7(ΔHep) mice) develop hepatoma, suggesting that autophagy deficiency could be a factor in the initiation of tumorigenesis. We have shown that FGF21 is induced as a ‘mitokine’ when Atg7 is disrupted in insulin target tissues such as th...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8936433/ https://www.ncbi.nlm.nih.gov/pubmed/35321438 http://dx.doi.org/10.3389/fonc.2022.832804 |