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Disruptions in hepatic glucose metabolism are involved in the diminished efficacy after chronic treatment with glucokinase activator
Glucokinase activators are regarded as potent candidates for diabetes treatment, however, in clinical studies on patients with type 2 diabetes, a diminishing efficacy was observed after chronic treatment with them. The mechanism of this reduction has not been elucidated, and whether it is a class ef...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8936481/ https://www.ncbi.nlm.nih.gov/pubmed/35312718 http://dx.doi.org/10.1371/journal.pone.0265761 |