Cargando…

Cytochrome P450 168A1 from Pseudomonas aeruginosa is involved in the hydroxylation of biologically relevant fatty acids

The cytochrome P450 CYP168A1 from Pseudomonas aeruginosa was cloned and expressed in Escherichia coli followed by purification and characterization of function. CYP168A1 is a fatty acid hydroxylase that hydroxylates saturated fatty acids, including myristic (0.30 min(-1)), palmitic (1.61 min(-1)) an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Price, Claire L., Warrilow, Andrew G. S., Rolley, Nicola J., Parker, Josie E., Thoss, Vera, Kelly, Diane E., Corcionivoschi, Nicolae, Kelly, Steven L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8936499/ https://www.ncbi.nlm.nih.gov/pubmed/35312722 http://dx.doi.org/10.1371/journal.pone.0265227

Ejemplares similares

Azole Antifungal Sensitivity of Sterol 14α-Demethylase (CYP51) and CYP5218 from Malassezia globosa
por: Warrilow, Andrew G. S., et al.
Publicado: (2016)

Pseudomonas aeruginosa cytochrome P450 CYP168A1 is a fatty acid hydroxylase that metabolizes arachidonic acid to the vasodilator 19-HETE
por: Tooker, Brian C., et al.
Publicado: (2022)

Hydroxylation of Antitubercular Drug Candidate, SQ109, by Mycobacterial Cytochrome P450
por: Bukhdruker, Sergey, et al.
Publicado: (2020)

Co-production of 11α-hydroxyprogesterone and ethanol using recombinant yeast expressing fungal steroid hydroxylases
por: Hull, Claire M., et al.
Publicado: (2017)

Regio‐ and Stereoselective Steroid Hydroxylation at C7 by Cytochrome P450 Monooxygenase Mutants
por: Li, Aitao, et al.
Publicado: (2020)

Exploring the Factors which Result in Cytochrome P450 Catalyzed Desaturation Versus Hydroxylation
por: Coleman, Tom, et al.
Publicado: (2022)

Cj1411c Encodes for a Cytochrome P450 Involved in Campylobacter jejuni 81-176 Pathogenicity
por: Alvarez, Luis A. J., et al.
Publicado: (2013)

Kinetic Analysis of Lauric Acid Hydroxylation by Human Cytochrome P450 4A11
por: Kim, Donghak, et al.
Publicado: (2014)

Role of cytochrome P450 2D6 genetic polymorphism in carvedilol hydroxylation in vitro
por: Wang, Zhe, et al.
Publicado: (2016)

Cloning and Expression of a Perilla frutescens Cytochrome P450 Enzyme Catalyzing the Hydroxylation of Phenylpropenes
por: Baba, Mariko, et al.
Publicado: (2020)

Enabling Aromatic Hydroxylation in a Cytochrome P450 Monooxygenase Enzyme through Protein Engineering
por: Coleman, Tom, et al.
Publicado: (2022)

Theoretical Study of Hydroxylation of α- and β-Pinene by a Cytochrome P450 Monooxygenase Model
por: Shaya, Janah, et al.
Publicado: (2023)

Tyrosine Hydroxylation in Betalain Pigment Biosynthesis Is Performed by Cytochrome P450 Enzymes in Beets (Beta vulgaris)
por: Sunnadeniya, Rasika, et al.
Publicado: (2016)

Computational Insight Into Vitamin K(1) ω-Hydroxylation by Cytochrome P450 4F2
por: Li, Junhao, et al.
Publicado: (2018)

Regioselective Hydroxylation of Phloretin, a Bioactive Compound from Apples, by Human Cytochrome P450 Enzymes
por: Nguyen, Ngoc Anh, et al.
Publicado: (2020)

Conversion of viridicatic acid to crustosic acid by cytochrome P450 enzyme-catalysed hydroxylation and spontaneous cyclisation
por: Zhou, Jenny, et al.
Publicado: (2021)

Cholesterol Hydroxylating Cytochrome P450 46A1: From Mechanisms of Action to Clinical Applications
por: Pikuleva, Irina A., et al.
Publicado: (2021)

The Evolution of Azole Resistance in Candida albicans Sterol 14α-Demethylase (CYP51) through Incremental Amino Acid Substitutions
por: Warrilow, Andrew G., et al.
Publicado: (2019)

Maximizing Biocatalytic Cyclohexane Hydroxylation by Modulating Cytochrome P450 Monooxygenase Expression in P. taiwanensis VLB120
por: Schäfer, Lisa, et al.
Publicado: (2020)

Exploring the Potential of Cytochrome P450 CYP109B1 Catalyzed Regio—and Stereoselective Steroid Hydroxylation
por: Zhang, Xiaodong, et al.
Publicado: (2021)

Human Orphan Cytochrome P450 2U1 Catalyzes the ω-Hydroxylation of Leukotriene B(4)
por: Nouri, Khawla, et al.
Publicado: (2022)

Characterization of kinetics of human cytochrome P450s involved in bioactivation of flucloxacillin: inhibition of CYP3A‐catalysed hydroxylation by sulfaphenazole
por: Dekker, Stefan J, et al.
Publicado: (2018)

On-line experience with the 168/E
por: Carroll, J T, et al.
Publicado: (1981)

An orphan cbb(3)-type cytochrome oxidase subunit supports Pseudomonas aeruginosa biofilm growth and virulence
por: Jo, Jeanyoung, et al.
Publicado: (2017)

Computational redesign of cytochrome P450 CYP102A1 for highly stereoselective omeprazole hydroxylation by UniDesign
por: Huang, Xiaoqiang, et al.
Publicado: (2023)

Genetic Basis and Physiological Effects of Lipid A Hydroxylation in Pseudomonas aeruginosa PAO1
por: Lo Sciuto, Alessandra, et al.
Publicado: (2019)

Binding interaction of a ring-hydroxylating dioxygenase with fluoranthene in Pseudomonas aeruginosa DN1
por: Xue, Shu-Wen, et al.
Publicado: (2021)

Biosynthetic flexibility of Pseudomonas aeruginosa leads to hydroxylated 2-alkylquinolones with proinflammatory host response
por: Savchenko, Viktoriia, et al.
Publicado: (2023)

Allosteric modulation of cytochrome P450 enzymes by the NADPH cytochrome P450 reductase FMN-containing domain
por: Burris-Hiday, Sarah D., et al.
Publicado: (2023)

Gallium-Protoporphyrin IX Inhibits Pseudomonas aeruginosa Growth by Targeting Cytochromes
por: Hijazi, Sarah, et al.
Publicado: (2017)

The Cytochrome P450 Homepage
por: Nelson, David R
Publicado: (2009)

Probing the Role of the Hinge Segment of Cytochrome P450 Oxidoreductase in the Interaction with Cytochrome P450
por: Campelo, Diana, et al.
Publicado: (2018)

Cytochrome P450-Mediated Phytoremediation using Transgenic Plants: A Need for Engineered Cytochrome P450 Enzymes
por: Kumar, Santosh, et al.
Publicado: (2012)

In Vitro Cytochrome P450 Formation of a Mono-Hydroxylated Metabolite of Zearalenone Exhibiting Estrogenic Activities: Possible Occurrence of This Metabolite in Vivo
por: Bravin, Frederique, et al.
Publicado: (2009)

Structure-Function Analysis of Porcine Cytochrome P450 3A29 in the Hydroxylation of T-2 Toxin as Revealed by Docking and Mutagenesis Studies
por: Cheng, Guyue, et al.
Publicado: (2014)

Studies on 16α-Hydroxylation of Steroid Molecules and Regioselective Binding Mode in Homology-Modeled Cytochrome P450-2C11
por: Ali, Hamed I., et al.
Publicado: (2011)

Functional characterization of the chlorzoxazone 6-hydroxylation activity of human cytochrome P450 2E1 allelic variants in Han Chinese
por: Wang, Ting, et al.
Publicado: (2020)

Latent Functions and Applications of Cytochrome P450 Monooxygenases from Thamnidium elegans: A Novel Biocatalyst for 14α-Hydroxylation of Testosterone
por: Permana, Dani, et al.
Publicado: (2022)

Small‐Molecule Inhibitors Targeting Sterol 14α‐Demethylase (CYP51): Synthesis, Molecular Modelling and Evaluation Against Candida albicans
por: Binjubair, Faizah A., et al.
Publicado: (2020)

The FMN “140s Loop” of Cytochrome P450 Reductase Controls Electron Transfer to Cytochrome P450
por: Rwere, Freeborn, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ovvb6degbkrknors5a7firte4h