p53 mutations define the chromatin landscape to confer drug tolerance in pancreatic cancer

Somatic inactivation of p53 (TP53) mainly occurs as missense mutations that lead to the acquisition of neomorphic mutant protein forms. p53 mutants have been postulated to exert gain‐of‐function (GOF) effects, including promotion of metastasis and drug tolerance, which generally contribute to the ac...

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Detalles Bibliográficos
Autores principales: Zampieri, Carlotta, Panatta, Emanuele, Corbo, Vincenzo, Mauriello, Alessandro, Melino, Gerry, Amelio, Ivano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8936522/
https://www.ncbi.nlm.nih.gov/pubmed/34919788
http://dx.doi.org/10.1002/1878-0261.13161

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8936522/
https://www.ncbi.nlm.nih.gov/pubmed/34919788
http://dx.doi.org/10.1002/1878-0261.13161

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