Intrinsic and acquired drug resistance to LSD1 inhibitors in small cell lung cancer occurs through a TEAD4‐driven transcriptional state

Small‐cell lung cancer (SCLC) is a heterogeneous disease, consisting of intratumoral and intertumoral neuroendocrine (ASCL1 and/or NEUROD1), mesenchymal‐like, and YAP‐driven transcriptional states. Lysine‐specific demethylase 1 (LSD1; also known as KDM1A) inhibitors have recently been progressed to...

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Detalles Bibliográficos
Autores principales: Yan, Wen, Chung, Chi‐Yeh, Xie, Tao, Ozeck, Mark, Nichols, Timothy C., Frey, Jessica, Udyavar, Akshata R., Sharma, Shikhar, Paul, Thomas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8936524/
https://www.ncbi.nlm.nih.gov/pubmed/34669238
http://dx.doi.org/10.1002/1878-0261.13124

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