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Recovery Profile of Sugammadex versus Neostigmine in Pediatric Patients Undergoing Cardiac Catheterization: A Randomized Double-Blind Study

BACKGROUND: Sugammadex is a selective reversal agent which has the ability to reverse deep neuromuscular blockade. However, there are still controversial results as regard sugammadex effects on the quality of recovery. We hypothesized that Sugammadex may have better recovery profile compared to neos...

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Autores principales: Saber, Hosam I. El Said, Mousa, Sherif A., AbouRezk, Ahmed Refaat, Zaglool, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8936865/
https://www.ncbi.nlm.nih.gov/pubmed/35320954
http://dx.doi.org/10.4103/aer.aer_139_21
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author Saber, Hosam I. El Said
Mousa, Sherif A.
AbouRezk, Ahmed Refaat
Zaglool, A
author_facet Saber, Hosam I. El Said
Mousa, Sherif A.
AbouRezk, Ahmed Refaat
Zaglool, A
author_sort Saber, Hosam I. El Said
collection PubMed
description BACKGROUND: Sugammadex is a selective reversal agent which has the ability to reverse deep neuromuscular blockade. However, there are still controversial results as regard sugammadex effects on the quality of recovery. We hypothesized that Sugammadex may have better recovery profile compared to neostigmine in pediatric patients with congenital heart diseases undergoing cardiac catheterization. PATIENTS AND METHODS: This prospective randomized double-blind study included 50 pediatric patients aged <2 years who were divided into two groups according to the reversal agent used; Group S (Sugammadex) and Group N (Neostigmine). Both groups received the same anesthetic technique during cardiac catheterization, and basic hemodynamic monitoring was ensured in both groups. After the procedure, reversal was done using 4 mg.kg(‒1) sugammadex or 0.04 mg. kg(‒1) neostigmine plus 0.02 mg. kg(‒1) atropine according to the group allocation. Recovery time and side effects were recorded. RESULTS: The two groups showed comparable findings regarding demographics. Nonetheless, the total time of anesthesia had mean values of 91.06 and 101.25 min in the two groups, respectively (P = 0.003), while recovery time had mean values of 1.61 and 9.23 min in the same groups, respectively (P < 0.001). Hemodynamic profile (heart rate and mean arterial pressure) was better after reversal with sugammadex. Blood sugar levels and side effects showed no significant difference between both groups. CONCLUSION: Sugammadex can be a more rapid and effective alternative to neostigmine for reversal of rocuronium-induced neuromuscular blockade in pediatric patients undergoing cardiac catheterization.
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spelling pubmed-89368652022-03-22 Recovery Profile of Sugammadex versus Neostigmine in Pediatric Patients Undergoing Cardiac Catheterization: A Randomized Double-Blind Study Saber, Hosam I. El Said Mousa, Sherif A. AbouRezk, Ahmed Refaat Zaglool, A Anesth Essays Res Original Article BACKGROUND: Sugammadex is a selective reversal agent which has the ability to reverse deep neuromuscular blockade. However, there are still controversial results as regard sugammadex effects on the quality of recovery. We hypothesized that Sugammadex may have better recovery profile compared to neostigmine in pediatric patients with congenital heart diseases undergoing cardiac catheterization. PATIENTS AND METHODS: This prospective randomized double-blind study included 50 pediatric patients aged <2 years who were divided into two groups according to the reversal agent used; Group S (Sugammadex) and Group N (Neostigmine). Both groups received the same anesthetic technique during cardiac catheterization, and basic hemodynamic monitoring was ensured in both groups. After the procedure, reversal was done using 4 mg.kg(‒1) sugammadex or 0.04 mg. kg(‒1) neostigmine plus 0.02 mg. kg(‒1) atropine according to the group allocation. Recovery time and side effects were recorded. RESULTS: The two groups showed comparable findings regarding demographics. Nonetheless, the total time of anesthesia had mean values of 91.06 and 101.25 min in the two groups, respectively (P = 0.003), while recovery time had mean values of 1.61 and 9.23 min in the same groups, respectively (P < 0.001). Hemodynamic profile (heart rate and mean arterial pressure) was better after reversal with sugammadex. Blood sugar levels and side effects showed no significant difference between both groups. CONCLUSION: Sugammadex can be a more rapid and effective alternative to neostigmine for reversal of rocuronium-induced neuromuscular blockade in pediatric patients undergoing cardiac catheterization. Wolters Kluwer - Medknow 2021 2022-02-07 /pmc/articles/PMC8936865/ /pubmed/35320954 http://dx.doi.org/10.4103/aer.aer_139_21 Text en Copyright: © 2022 Anesthesia: Essays and Researches https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Saber, Hosam I. El Said
Mousa, Sherif A.
AbouRezk, Ahmed Refaat
Zaglool, A
Recovery Profile of Sugammadex versus Neostigmine in Pediatric Patients Undergoing Cardiac Catheterization: A Randomized Double-Blind Study
title Recovery Profile of Sugammadex versus Neostigmine in Pediatric Patients Undergoing Cardiac Catheterization: A Randomized Double-Blind Study
title_full Recovery Profile of Sugammadex versus Neostigmine in Pediatric Patients Undergoing Cardiac Catheterization: A Randomized Double-Blind Study
title_fullStr Recovery Profile of Sugammadex versus Neostigmine in Pediatric Patients Undergoing Cardiac Catheterization: A Randomized Double-Blind Study
title_full_unstemmed Recovery Profile of Sugammadex versus Neostigmine in Pediatric Patients Undergoing Cardiac Catheterization: A Randomized Double-Blind Study
title_short Recovery Profile of Sugammadex versus Neostigmine in Pediatric Patients Undergoing Cardiac Catheterization: A Randomized Double-Blind Study
title_sort recovery profile of sugammadex versus neostigmine in pediatric patients undergoing cardiac catheterization: a randomized double-blind study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8936865/
https://www.ncbi.nlm.nih.gov/pubmed/35320954
http://dx.doi.org/10.4103/aer.aer_139_21
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