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Vitamin D as a Potential Preventive Agent For Young Women's Breast Cancer
Clinical studies backed by research in animal models suggest that vitamin D may protect against the development of breast cancer, implicating vitamin D as a promising candidate for breast cancer prevention. However, despite clear preclinical evidence showing protective roles for vitamin D, broadly t...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for Cancer Research
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8937000/ https://www.ncbi.nlm.nih.gov/pubmed/34244152 http://dx.doi.org/10.1158/1940-6207.CAPR-21-0114 |
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author | Bernhardt, Sarah M. Borges, Virginia F. Schedin, Pepper |
author_facet | Bernhardt, Sarah M. Borges, Virginia F. Schedin, Pepper |
author_sort | Bernhardt, Sarah M. |
collection | PubMed |
description | Clinical studies backed by research in animal models suggest that vitamin D may protect against the development of breast cancer, implicating vitamin D as a promising candidate for breast cancer prevention. However, despite clear preclinical evidence showing protective roles for vitamin D, broadly targeted clinical trials of vitamin D supplementation have yielded conflicting findings, highlighting the complexity of translating preclinical data to efficacy in humans. While vitamin D supplementation targeted to high-risk populations is a strategy anticipated to increase prevention efficacy, a complimentary approach is to target transient, developmental windows of elevated breast cancer risk. Postpartum mammary gland involution represents a developmental window of increased breast cancer promotion that may be poised for vitamin D supplementation. Targeting the window of involution with short-term vitamin D intervention may offer a simple, cost-effective approach for the prevention of breast cancers that develop postpartum. In this review, we highlight epidemiologic and preclinical studies linking vitamin D deficiency with breast cancer development. We discuss the underlying mechanisms through which vitamin D deficiency contributes to cancer development, with an emphasis on the anti-inflammatory activity of vitamin D. We also discuss current evidence for vitamin D as an immunotherapeutic agent and the potential for vitamin D as a preventative strategy for young woman's breast cancer. |
format | Online Article Text |
id | pubmed-8937000 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | American Association for Cancer Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-89370002022-03-21 Vitamin D as a Potential Preventive Agent For Young Women's Breast Cancer Bernhardt, Sarah M. Borges, Virginia F. Schedin, Pepper Cancer Prev Res (Phila) Review Clinical studies backed by research in animal models suggest that vitamin D may protect against the development of breast cancer, implicating vitamin D as a promising candidate for breast cancer prevention. However, despite clear preclinical evidence showing protective roles for vitamin D, broadly targeted clinical trials of vitamin D supplementation have yielded conflicting findings, highlighting the complexity of translating preclinical data to efficacy in humans. While vitamin D supplementation targeted to high-risk populations is a strategy anticipated to increase prevention efficacy, a complimentary approach is to target transient, developmental windows of elevated breast cancer risk. Postpartum mammary gland involution represents a developmental window of increased breast cancer promotion that may be poised for vitamin D supplementation. Targeting the window of involution with short-term vitamin D intervention may offer a simple, cost-effective approach for the prevention of breast cancers that develop postpartum. In this review, we highlight epidemiologic and preclinical studies linking vitamin D deficiency with breast cancer development. We discuss the underlying mechanisms through which vitamin D deficiency contributes to cancer development, with an emphasis on the anti-inflammatory activity of vitamin D. We also discuss current evidence for vitamin D as an immunotherapeutic agent and the potential for vitamin D as a preventative strategy for young woman's breast cancer. American Association for Cancer Research 2021-09 2021-07-09 /pmc/articles/PMC8937000/ /pubmed/34244152 http://dx.doi.org/10.1158/1940-6207.CAPR-21-0114 Text en ©2021 The Authors; Published by the American Association for Cancer Research https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs International 4.0 License. |
spellingShingle | Review Bernhardt, Sarah M. Borges, Virginia F. Schedin, Pepper Vitamin D as a Potential Preventive Agent For Young Women's Breast Cancer |
title | Vitamin D as a Potential Preventive Agent For Young Women's Breast Cancer |
title_full | Vitamin D as a Potential Preventive Agent For Young Women's Breast Cancer |
title_fullStr | Vitamin D as a Potential Preventive Agent For Young Women's Breast Cancer |
title_full_unstemmed | Vitamin D as a Potential Preventive Agent For Young Women's Breast Cancer |
title_short | Vitamin D as a Potential Preventive Agent For Young Women's Breast Cancer |
title_sort | vitamin d as a potential preventive agent for young women's breast cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8937000/ https://www.ncbi.nlm.nih.gov/pubmed/34244152 http://dx.doi.org/10.1158/1940-6207.CAPR-21-0114 |
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