Receptor tyrosine kinases regulate signal transduction through a liquid-liquid phase separated state

The recruitment of signaling proteins into activated receptor tyrosine kinases (RTKs) to produce rapid, high-fidelity downstream response is exposed to the ambiguity of random diffusion to the target site. Liquid-liquid phase separation (LLPS) overcomes this by providing elevated, localized concentr...

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Detalles Bibliográficos
Autores principales: Lin, Chi-Chuan, Suen, Kin Man, Jeffrey, Polly-Anne, Wieteska, Lukasz, Lidster, Jessica A., Bao, Peng, Curd, Alistair P., Stainthorp, Amy, Seiler, Caroline, Koss, Hans, Miska, Eric, Ahmed, Zamal, Evans, Stephen D., Molina-París, Carmen, Ladbury, John E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8937303/
https://www.ncbi.nlm.nih.gov/pubmed/35231400
http://dx.doi.org/10.1016/j.molcel.2022.02.005

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