Fusobacterium nucleatum and Colorectal Cancer

Fusobacterium nucleatum (F.n) is an oral anaerobic gram-negative bacillus that can colonize into the colon tissues through bloodstream infection. F.n have been found to be involved in both the occurrence and metastasis of colorectal cancer (CRC) through regulating immune response, virulence factor,...

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Detalles Bibliográficos
Autores principales: Li, Rongrong, Shen, Jilu, Xu, Yuanhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8937307/
https://www.ncbi.nlm.nih.gov/pubmed/35321079
http://dx.doi.org/10.2147/IDR.S357922
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author Li, Rongrong
Shen, Jilu
Xu, Yuanhong
author_facet Li, Rongrong
Shen, Jilu
Xu, Yuanhong
author_sort Li, Rongrong
collection PubMed
description Fusobacterium nucleatum (F.n) is an oral anaerobic gram-negative bacillus that can colonize into the colon tissues through bloodstream infection. F.n have been found to be involved in both the occurrence and metastasis of colorectal cancer (CRC) through regulating immune response, virulence factor, oncogenic microRNAs, intestinal metabolites, DNA damage and other mechanisms. Therefore, F.n can be as an important pathogenic risk factor and a possible biomarker of CRC. Based on this, we have summarized the potential relationship between F.n and CRC to provide reference for the targeted therapy of CRC.
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spelling pubmed-89373072022-03-22 Fusobacterium nucleatum and Colorectal Cancer Li, Rongrong Shen, Jilu Xu, Yuanhong Infect Drug Resist Review Fusobacterium nucleatum (F.n) is an oral anaerobic gram-negative bacillus that can colonize into the colon tissues through bloodstream infection. F.n have been found to be involved in both the occurrence and metastasis of colorectal cancer (CRC) through regulating immune response, virulence factor, oncogenic microRNAs, intestinal metabolites, DNA damage and other mechanisms. Therefore, F.n can be as an important pathogenic risk factor and a possible biomarker of CRC. Based on this, we have summarized the potential relationship between F.n and CRC to provide reference for the targeted therapy of CRC. Dove 2022-03-17 /pmc/articles/PMC8937307/ /pubmed/35321079 http://dx.doi.org/10.2147/IDR.S357922 Text en © 2022 Li et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Li, Rongrong
Shen, Jilu
Xu, Yuanhong
Fusobacterium nucleatum and Colorectal Cancer
title Fusobacterium nucleatum and Colorectal Cancer
title_full Fusobacterium nucleatum and Colorectal Cancer
title_fullStr Fusobacterium nucleatum and Colorectal Cancer
title_full_unstemmed Fusobacterium nucleatum and Colorectal Cancer
title_short Fusobacterium nucleatum and Colorectal Cancer
title_sort fusobacterium nucleatum and colorectal cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8937307/
https://www.ncbi.nlm.nih.gov/pubmed/35321079
http://dx.doi.org/10.2147/IDR.S357922
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