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An evolutionary insight into Severe Acute Respiratory Syndrome Coronavirus 2 Omicron variant of concern.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel virus that belongs to the family Coronaviridae. This virus produces a respiratory illness known as coronavirus disease 2019 (COVID-19) and is to blame for the pandemic of COVID-19. Due to its massive circulation around the world...

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Autores principales: Paz, Mercedes, Aldunate, Fabián, Arce, Rodrigo, Ferreiro, Irene, Cristina, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier B.V. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8937608/
https://www.ncbi.nlm.nih.gov/pubmed/35331836
http://dx.doi.org/10.1016/j.virusres.2022.198753
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author Paz, Mercedes
Aldunate, Fabián
Arce, Rodrigo
Ferreiro, Irene
Cristina, Juan
author_facet Paz, Mercedes
Aldunate, Fabián
Arce, Rodrigo
Ferreiro, Irene
Cristina, Juan
author_sort Paz, Mercedes
collection PubMed
description Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel virus that belongs to the family Coronaviridae. This virus produces a respiratory illness known as coronavirus disease 2019 (COVID-19) and is to blame for the pandemic of COVID-19. Due to its massive circulation around the world and the capacity of mutation of this virus, genomic studies are much needed in to order to reveal new variants of concern (VOCs). On November 26th, 2021, the WHO announced that a new SARS-CoV-2 VOC, named Omicron, had emerged. In order to get insight into the emergence, spread and evolution of Omicron SARS-CoV-2 variants, a comprehensive phylogenetic study was performed. The results of these studies revealed significant differences in codon usage among the S genes of SARS-CoV-2 VOCs Alfa, Beta, Gamma, Delta and Omicron, which can be linked to SARS-CoV-2 genotypes. Omicron variant did not evolve out of one of the early VOCs, but instead it belongs to a complete different genetic lineage from previous ones. Strains classified as Omicron variants evolved from ancestors that existed around May 15th, 2020, suggesting that this VOC may have been circulating undetected for a period of time until its emergence was observed in South Africa. A rate of evolution of 5.61 × 10(−4) substitutions/site/year was found for Omicron strains enrolled in these analyses. The results of these studies demonstrate that S genes have suitable genetic information for clear assignment of emerging VOCs to its specific genotypes.
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spelling pubmed-89376082022-03-22 An evolutionary insight into Severe Acute Respiratory Syndrome Coronavirus 2 Omicron variant of concern. Paz, Mercedes Aldunate, Fabián Arce, Rodrigo Ferreiro, Irene Cristina, Juan Virus Res Article Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel virus that belongs to the family Coronaviridae. This virus produces a respiratory illness known as coronavirus disease 2019 (COVID-19) and is to blame for the pandemic of COVID-19. Due to its massive circulation around the world and the capacity of mutation of this virus, genomic studies are much needed in to order to reveal new variants of concern (VOCs). On November 26th, 2021, the WHO announced that a new SARS-CoV-2 VOC, named Omicron, had emerged. In order to get insight into the emergence, spread and evolution of Omicron SARS-CoV-2 variants, a comprehensive phylogenetic study was performed. The results of these studies revealed significant differences in codon usage among the S genes of SARS-CoV-2 VOCs Alfa, Beta, Gamma, Delta and Omicron, which can be linked to SARS-CoV-2 genotypes. Omicron variant did not evolve out of one of the early VOCs, but instead it belongs to a complete different genetic lineage from previous ones. Strains classified as Omicron variants evolved from ancestors that existed around May 15th, 2020, suggesting that this VOC may have been circulating undetected for a period of time until its emergence was observed in South Africa. A rate of evolution of 5.61 × 10(−4) substitutions/site/year was found for Omicron strains enrolled in these analyses. The results of these studies demonstrate that S genes have suitable genetic information for clear assignment of emerging VOCs to its specific genotypes. Published by Elsevier B.V. 2022-06 2022-03-22 /pmc/articles/PMC8937608/ /pubmed/35331836 http://dx.doi.org/10.1016/j.virusres.2022.198753 Text en © 2022 Published by Elsevier B.V. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Paz, Mercedes
Aldunate, Fabián
Arce, Rodrigo
Ferreiro, Irene
Cristina, Juan
An evolutionary insight into Severe Acute Respiratory Syndrome Coronavirus 2 Omicron variant of concern.
title An evolutionary insight into Severe Acute Respiratory Syndrome Coronavirus 2 Omicron variant of concern.
title_full An evolutionary insight into Severe Acute Respiratory Syndrome Coronavirus 2 Omicron variant of concern.
title_fullStr An evolutionary insight into Severe Acute Respiratory Syndrome Coronavirus 2 Omicron variant of concern.
title_full_unstemmed An evolutionary insight into Severe Acute Respiratory Syndrome Coronavirus 2 Omicron variant of concern.
title_short An evolutionary insight into Severe Acute Respiratory Syndrome Coronavirus 2 Omicron variant of concern.
title_sort evolutionary insight into severe acute respiratory syndrome coronavirus 2 omicron variant of concern.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8937608/
https://www.ncbi.nlm.nih.gov/pubmed/35331836
http://dx.doi.org/10.1016/j.virusres.2022.198753
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