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Identified human breast milk compositions effectively inhibit SARS-CoV-2 and variants infection and replication
The global pandemic of COVID-19 caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection confers great threat to public health. Human breast milk is a complex nutritional composition to nourish infants and protect them from different kinds of infectious diseases including...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8937612/ https://www.ncbi.nlm.nih.gov/pubmed/35342878 http://dx.doi.org/10.1016/j.isci.2022.104136 |
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author | Lai, Xinyuan Yu, Yanying Xian, Wei Ye, Fei Ju, Xiaohui Luo, Yuqian Dong, Huijun Zhou, Yi-Hua Tan, Wenjie Zhuang, Hui Li, Tong Liu, Xiaoyun Ding, Qiang Xiang, Kuanhui |
author_facet | Lai, Xinyuan Yu, Yanying Xian, Wei Ye, Fei Ju, Xiaohui Luo, Yuqian Dong, Huijun Zhou, Yi-Hua Tan, Wenjie Zhuang, Hui Li, Tong Liu, Xiaoyun Ding, Qiang Xiang, Kuanhui |
author_sort | Lai, Xinyuan |
collection | PubMed |
description | The global pandemic of COVID-19 caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection confers great threat to public health. Human breast milk is a complex nutritional composition to nourish infants and protect them from different kinds of infectious diseases including COVID-19. Here, we identified that lactoferrin (LF), mucin1 (MUC1), and α-lactalbumin (α-LA) from human breast milk inhibit SARS-CoV-2 infection using a SARS-CoV-2 pseudovirus system and transcription and replication-competent SARS-CoV-2 virus-like-particles (trVLP). In addition, LF and MUC1 inhibited multiple steps including viral attachment, entry, and postentry replication, whereas α-LA inhibited viral attachment and entry. Importantly, LF, MUC1, and α-LA possess potent antiviral activities toward variants such as B.1.1.7 (alpha), B.1.351 (beta), P.1 (gamma), and B.1.617.1 (kappa). Taken together, our study provides evidence that human breast milk components (LF, MUC1, and α-LA) are promising antiviral and potential therapeutic candidates warranting further development for treating COVID-19. |
format | Online Article Text |
id | pubmed-8937612 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-89376122022-03-22 Identified human breast milk compositions effectively inhibit SARS-CoV-2 and variants infection and replication Lai, Xinyuan Yu, Yanying Xian, Wei Ye, Fei Ju, Xiaohui Luo, Yuqian Dong, Huijun Zhou, Yi-Hua Tan, Wenjie Zhuang, Hui Li, Tong Liu, Xiaoyun Ding, Qiang Xiang, Kuanhui iScience Article The global pandemic of COVID-19 caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection confers great threat to public health. Human breast milk is a complex nutritional composition to nourish infants and protect them from different kinds of infectious diseases including COVID-19. Here, we identified that lactoferrin (LF), mucin1 (MUC1), and α-lactalbumin (α-LA) from human breast milk inhibit SARS-CoV-2 infection using a SARS-CoV-2 pseudovirus system and transcription and replication-competent SARS-CoV-2 virus-like-particles (trVLP). In addition, LF and MUC1 inhibited multiple steps including viral attachment, entry, and postentry replication, whereas α-LA inhibited viral attachment and entry. Importantly, LF, MUC1, and α-LA possess potent antiviral activities toward variants such as B.1.1.7 (alpha), B.1.351 (beta), P.1 (gamma), and B.1.617.1 (kappa). Taken together, our study provides evidence that human breast milk components (LF, MUC1, and α-LA) are promising antiviral and potential therapeutic candidates warranting further development for treating COVID-19. Elsevier 2022-03-22 /pmc/articles/PMC8937612/ /pubmed/35342878 http://dx.doi.org/10.1016/j.isci.2022.104136 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Lai, Xinyuan Yu, Yanying Xian, Wei Ye, Fei Ju, Xiaohui Luo, Yuqian Dong, Huijun Zhou, Yi-Hua Tan, Wenjie Zhuang, Hui Li, Tong Liu, Xiaoyun Ding, Qiang Xiang, Kuanhui Identified human breast milk compositions effectively inhibit SARS-CoV-2 and variants infection and replication |
title | Identified human breast milk compositions effectively inhibit SARS-CoV-2 and variants infection and replication |
title_full | Identified human breast milk compositions effectively inhibit SARS-CoV-2 and variants infection and replication |
title_fullStr | Identified human breast milk compositions effectively inhibit SARS-CoV-2 and variants infection and replication |
title_full_unstemmed | Identified human breast milk compositions effectively inhibit SARS-CoV-2 and variants infection and replication |
title_short | Identified human breast milk compositions effectively inhibit SARS-CoV-2 and variants infection and replication |
title_sort | identified human breast milk compositions effectively inhibit sars-cov-2 and variants infection and replication |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8937612/ https://www.ncbi.nlm.nih.gov/pubmed/35342878 http://dx.doi.org/10.1016/j.isci.2022.104136 |
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