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Research Progress on Targeted Antioxidant Therapy and Vitiligo
Vitiligo is a common acquired depigmenting disease characterized by the loss of functional melanocytes and epidermal melanin. Vitiligo has a long treatment cycle and slow results, which is one of the most difficult challenges for skin diseases. Oxidative stress plays an important role as an initiati...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938057/ https://www.ncbi.nlm.nih.gov/pubmed/35320978 http://dx.doi.org/10.1155/2022/1821780 |
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author | Zhang, Jingzhan Hu, Wen Wang, Peng Ding, Yuan Wang, Hongjuan Kang, Xiaojing |
author_facet | Zhang, Jingzhan Hu, Wen Wang, Peng Ding, Yuan Wang, Hongjuan Kang, Xiaojing |
author_sort | Zhang, Jingzhan |
collection | PubMed |
description | Vitiligo is a common acquired depigmenting disease characterized by the loss of functional melanocytes and epidermal melanin. Vitiligo has a long treatment cycle and slow results, which is one of the most difficult challenges for skin diseases. Oxidative stress plays an important role as an initiating and driving factor in the pathogenesis of vitiligo. Antioxidant therapy has recently become a research hotspot in vitiligo treatment. A series of antioxidants has been discovered and applied to the treatment of vitiligo, which has returned satisfactory results. This article briefly reviews the relationship between oxidative stress and vitiligo. We also describe the progress of targeted antioxidant therapy in vitiligo, with the aim of providing a reference for new drug development and treatment options for this condition. |
format | Online Article Text |
id | pubmed-8938057 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-89380572022-03-22 Research Progress on Targeted Antioxidant Therapy and Vitiligo Zhang, Jingzhan Hu, Wen Wang, Peng Ding, Yuan Wang, Hongjuan Kang, Xiaojing Oxid Med Cell Longev Review Article Vitiligo is a common acquired depigmenting disease characterized by the loss of functional melanocytes and epidermal melanin. Vitiligo has a long treatment cycle and slow results, which is one of the most difficult challenges for skin diseases. Oxidative stress plays an important role as an initiating and driving factor in the pathogenesis of vitiligo. Antioxidant therapy has recently become a research hotspot in vitiligo treatment. A series of antioxidants has been discovered and applied to the treatment of vitiligo, which has returned satisfactory results. This article briefly reviews the relationship between oxidative stress and vitiligo. We also describe the progress of targeted antioxidant therapy in vitiligo, with the aim of providing a reference for new drug development and treatment options for this condition. Hindawi 2022-03-14 /pmc/articles/PMC8938057/ /pubmed/35320978 http://dx.doi.org/10.1155/2022/1821780 Text en Copyright © 2022 Jingzhan Zhang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Zhang, Jingzhan Hu, Wen Wang, Peng Ding, Yuan Wang, Hongjuan Kang, Xiaojing Research Progress on Targeted Antioxidant Therapy and Vitiligo |
title | Research Progress on Targeted Antioxidant Therapy and Vitiligo |
title_full | Research Progress on Targeted Antioxidant Therapy and Vitiligo |
title_fullStr | Research Progress on Targeted Antioxidant Therapy and Vitiligo |
title_full_unstemmed | Research Progress on Targeted Antioxidant Therapy and Vitiligo |
title_short | Research Progress on Targeted Antioxidant Therapy and Vitiligo |
title_sort | research progress on targeted antioxidant therapy and vitiligo |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938057/ https://www.ncbi.nlm.nih.gov/pubmed/35320978 http://dx.doi.org/10.1155/2022/1821780 |
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