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Research Progress on Targeted Antioxidant Therapy and Vitiligo

Vitiligo is a common acquired depigmenting disease characterized by the loss of functional melanocytes and epidermal melanin. Vitiligo has a long treatment cycle and slow results, which is one of the most difficult challenges for skin diseases. Oxidative stress plays an important role as an initiati...

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Autores principales: Zhang, Jingzhan, Hu, Wen, Wang, Peng, Ding, Yuan, Wang, Hongjuan, Kang, Xiaojing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938057/
https://www.ncbi.nlm.nih.gov/pubmed/35320978
http://dx.doi.org/10.1155/2022/1821780
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author Zhang, Jingzhan
Hu, Wen
Wang, Peng
Ding, Yuan
Wang, Hongjuan
Kang, Xiaojing
author_facet Zhang, Jingzhan
Hu, Wen
Wang, Peng
Ding, Yuan
Wang, Hongjuan
Kang, Xiaojing
author_sort Zhang, Jingzhan
collection PubMed
description Vitiligo is a common acquired depigmenting disease characterized by the loss of functional melanocytes and epidermal melanin. Vitiligo has a long treatment cycle and slow results, which is one of the most difficult challenges for skin diseases. Oxidative stress plays an important role as an initiating and driving factor in the pathogenesis of vitiligo. Antioxidant therapy has recently become a research hotspot in vitiligo treatment. A series of antioxidants has been discovered and applied to the treatment of vitiligo, which has returned satisfactory results. This article briefly reviews the relationship between oxidative stress and vitiligo. We also describe the progress of targeted antioxidant therapy in vitiligo, with the aim of providing a reference for new drug development and treatment options for this condition.
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spelling pubmed-89380572022-03-22 Research Progress on Targeted Antioxidant Therapy and Vitiligo Zhang, Jingzhan Hu, Wen Wang, Peng Ding, Yuan Wang, Hongjuan Kang, Xiaojing Oxid Med Cell Longev Review Article Vitiligo is a common acquired depigmenting disease characterized by the loss of functional melanocytes and epidermal melanin. Vitiligo has a long treatment cycle and slow results, which is one of the most difficult challenges for skin diseases. Oxidative stress plays an important role as an initiating and driving factor in the pathogenesis of vitiligo. Antioxidant therapy has recently become a research hotspot in vitiligo treatment. A series of antioxidants has been discovered and applied to the treatment of vitiligo, which has returned satisfactory results. This article briefly reviews the relationship between oxidative stress and vitiligo. We also describe the progress of targeted antioxidant therapy in vitiligo, with the aim of providing a reference for new drug development and treatment options for this condition. Hindawi 2022-03-14 /pmc/articles/PMC8938057/ /pubmed/35320978 http://dx.doi.org/10.1155/2022/1821780 Text en Copyright © 2022 Jingzhan Zhang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Zhang, Jingzhan
Hu, Wen
Wang, Peng
Ding, Yuan
Wang, Hongjuan
Kang, Xiaojing
Research Progress on Targeted Antioxidant Therapy and Vitiligo
title Research Progress on Targeted Antioxidant Therapy and Vitiligo
title_full Research Progress on Targeted Antioxidant Therapy and Vitiligo
title_fullStr Research Progress on Targeted Antioxidant Therapy and Vitiligo
title_full_unstemmed Research Progress on Targeted Antioxidant Therapy and Vitiligo
title_short Research Progress on Targeted Antioxidant Therapy and Vitiligo
title_sort research progress on targeted antioxidant therapy and vitiligo
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938057/
https://www.ncbi.nlm.nih.gov/pubmed/35320978
http://dx.doi.org/10.1155/2022/1821780
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