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Prognostic and Diagnostic Value of Endocan in Kidney Diseases
Endocan, previously called endothelial cell-specific molecule-1, is a soluble proteoglycan that is predominantly expressed in vascular endothelial cells of the lungs and kidneys. It is upregulated by proinflammatory cytokines and plays a critical role in inflammatory, proliferative, and neovasculari...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938144/ https://www.ncbi.nlm.nih.gov/pubmed/35321346 http://dx.doi.org/10.1155/2022/3861092 |
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author | Samouilidou, Elisabeth Athanasiadou, Virginia Grapsa, Eirini |
author_facet | Samouilidou, Elisabeth Athanasiadou, Virginia Grapsa, Eirini |
author_sort | Samouilidou, Elisabeth |
collection | PubMed |
description | Endocan, previously called endothelial cell-specific molecule-1, is a soluble proteoglycan that is predominantly expressed in vascular endothelial cells of the lungs and kidneys. It is upregulated by proinflammatory cytokines and plays a critical role in inflammatory, proliferative, and neovascularization processes. The utility of endocan as a biomarker in a wide spectrum of diseases is being increasingly acknowledged. In this review, we summarize the current evidence concerning the role of endocan in kidney diseases, with emphasis on its prognostic and diagnostic value. It seems that the determination of plasma endocan levels may provide useful prognostic information in many types of renal failure such as chronic kidney disease, IgA nephropathy, and diabetic nephropathy. Endocan could additionally improve the early diagnostic evaluation of acute kidney disease, chronic renal allograft injury, and acute rejection after kidney transplantation, thus contributing to endothelial cell injury monitoring in a timely manner. |
format | Online Article Text |
id | pubmed-8938144 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-89381442022-03-22 Prognostic and Diagnostic Value of Endocan in Kidney Diseases Samouilidou, Elisabeth Athanasiadou, Virginia Grapsa, Eirini Int J Nephrol Review Article Endocan, previously called endothelial cell-specific molecule-1, is a soluble proteoglycan that is predominantly expressed in vascular endothelial cells of the lungs and kidneys. It is upregulated by proinflammatory cytokines and plays a critical role in inflammatory, proliferative, and neovascularization processes. The utility of endocan as a biomarker in a wide spectrum of diseases is being increasingly acknowledged. In this review, we summarize the current evidence concerning the role of endocan in kidney diseases, with emphasis on its prognostic and diagnostic value. It seems that the determination of plasma endocan levels may provide useful prognostic information in many types of renal failure such as chronic kidney disease, IgA nephropathy, and diabetic nephropathy. Endocan could additionally improve the early diagnostic evaluation of acute kidney disease, chronic renal allograft injury, and acute rejection after kidney transplantation, thus contributing to endothelial cell injury monitoring in a timely manner. Hindawi 2022-03-14 /pmc/articles/PMC8938144/ /pubmed/35321346 http://dx.doi.org/10.1155/2022/3861092 Text en Copyright © 2022 Elisabeth Samouilidou et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Samouilidou, Elisabeth Athanasiadou, Virginia Grapsa, Eirini Prognostic and Diagnostic Value of Endocan in Kidney Diseases |
title | Prognostic and Diagnostic Value of Endocan in Kidney Diseases |
title_full | Prognostic and Diagnostic Value of Endocan in Kidney Diseases |
title_fullStr | Prognostic and Diagnostic Value of Endocan in Kidney Diseases |
title_full_unstemmed | Prognostic and Diagnostic Value of Endocan in Kidney Diseases |
title_short | Prognostic and Diagnostic Value of Endocan in Kidney Diseases |
title_sort | prognostic and diagnostic value of endocan in kidney diseases |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938144/ https://www.ncbi.nlm.nih.gov/pubmed/35321346 http://dx.doi.org/10.1155/2022/3861092 |
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