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Prognostic and Diagnostic Value of Endocan in Kidney Diseases

Endocan, previously called endothelial cell-specific molecule-1, is a soluble proteoglycan that is predominantly expressed in vascular endothelial cells of the lungs and kidneys. It is upregulated by proinflammatory cytokines and plays a critical role in inflammatory, proliferative, and neovasculari...

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Detalles Bibliográficos
Autores principales: Samouilidou, Elisabeth, Athanasiadou, Virginia, Grapsa, Eirini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938144/
https://www.ncbi.nlm.nih.gov/pubmed/35321346
http://dx.doi.org/10.1155/2022/3861092
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author Samouilidou, Elisabeth
Athanasiadou, Virginia
Grapsa, Eirini
author_facet Samouilidou, Elisabeth
Athanasiadou, Virginia
Grapsa, Eirini
author_sort Samouilidou, Elisabeth
collection PubMed
description Endocan, previously called endothelial cell-specific molecule-1, is a soluble proteoglycan that is predominantly expressed in vascular endothelial cells of the lungs and kidneys. It is upregulated by proinflammatory cytokines and plays a critical role in inflammatory, proliferative, and neovascularization processes. The utility of endocan as a biomarker in a wide spectrum of diseases is being increasingly acknowledged. In this review, we summarize the current evidence concerning the role of endocan in kidney diseases, with emphasis on its prognostic and diagnostic value. It seems that the determination of plasma endocan levels may provide useful prognostic information in many types of renal failure such as chronic kidney disease, IgA nephropathy, and diabetic nephropathy. Endocan could additionally improve the early diagnostic evaluation of acute kidney disease, chronic renal allograft injury, and acute rejection after kidney transplantation, thus contributing to endothelial cell injury monitoring in a timely manner.
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spelling pubmed-89381442022-03-22 Prognostic and Diagnostic Value of Endocan in Kidney Diseases Samouilidou, Elisabeth Athanasiadou, Virginia Grapsa, Eirini Int J Nephrol Review Article Endocan, previously called endothelial cell-specific molecule-1, is a soluble proteoglycan that is predominantly expressed in vascular endothelial cells of the lungs and kidneys. It is upregulated by proinflammatory cytokines and plays a critical role in inflammatory, proliferative, and neovascularization processes. The utility of endocan as a biomarker in a wide spectrum of diseases is being increasingly acknowledged. In this review, we summarize the current evidence concerning the role of endocan in kidney diseases, with emphasis on its prognostic and diagnostic value. It seems that the determination of plasma endocan levels may provide useful prognostic information in many types of renal failure such as chronic kidney disease, IgA nephropathy, and diabetic nephropathy. Endocan could additionally improve the early diagnostic evaluation of acute kidney disease, chronic renal allograft injury, and acute rejection after kidney transplantation, thus contributing to endothelial cell injury monitoring in a timely manner. Hindawi 2022-03-14 /pmc/articles/PMC8938144/ /pubmed/35321346 http://dx.doi.org/10.1155/2022/3861092 Text en Copyright © 2022 Elisabeth Samouilidou et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Samouilidou, Elisabeth
Athanasiadou, Virginia
Grapsa, Eirini
Prognostic and Diagnostic Value of Endocan in Kidney Diseases
title Prognostic and Diagnostic Value of Endocan in Kidney Diseases
title_full Prognostic and Diagnostic Value of Endocan in Kidney Diseases
title_fullStr Prognostic and Diagnostic Value of Endocan in Kidney Diseases
title_full_unstemmed Prognostic and Diagnostic Value of Endocan in Kidney Diseases
title_short Prognostic and Diagnostic Value of Endocan in Kidney Diseases
title_sort prognostic and diagnostic value of endocan in kidney diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938144/
https://www.ncbi.nlm.nih.gov/pubmed/35321346
http://dx.doi.org/10.1155/2022/3861092
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