Comparative functional genomics identifies an iron-limited bottleneck in a Saccharomyces cerevisiae strain with a cytosolic-localized isobutanol pathway

Metabolic engineering strategies have been successfully implemented to improve the production of isobutanol, a next-generation biofuel, in Saccharomyces cerevisiae. Here, we explore how two of these strategies, pathway re-localization and redox cofactor-balancing, affect the performance and physiolo...

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Detalles Bibliográficos
Autores principales: Gambacorta, Francesca V., Wagner, Ellen R., Jacobson, Tyler B., Tremaine, Mary, Muehlbauer, Laura K., McGee, Mick A., Baerwald, Justin J., Wrobel, Russell L., Wolters, John F., Place, Mike, Dietrich, Joshua J., Xie, Dan, Serate, Jose, Gajbhiye, Shabda, Liu, Lisa, Vang-Smith, Maikayeng, Coon, Joshua J., Zhang, Yaoping, Gasch, Audrey P., Amador-Noguez, Daniel, Hittinger, Chris Todd, Sato, Trey K., Pfleger, Brian F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2022
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938195/
https://www.ncbi.nlm.nih.gov/pubmed/35387233
http://dx.doi.org/10.1016/j.synbio.2022.02.007

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