Caloforines A–G, coumarins from the bark of Calophyllum scriblitifolium

Bioactivity-guided separation of the methanol extract of Calophyllum scriblitifolium bark led to the isolation of five new pyranocoumarins, caloforines A–E (1–5) and two new coumarins, caloforines F and G (6 and 7). Their structures were elucidated by 1D and 2D NMR spectroscopy, and their absolute c...

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Detalles Bibliográficos
Autores principales: Ogasawara, Ai, Noguchi, Ryo, Shigi, Takuya, Nugroho, Alfarius Eko, Hirasawa, Yusuke, Kaneda, Toshio, Tougan, Takahiro, Horii, Toshihiro, Hadi, A. Hamid A., Morita, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938217/
https://www.ncbi.nlm.nih.gov/pubmed/35316467
http://dx.doi.org/10.1007/s11418-022-01613-6
Descripción
Sumario:Bioactivity-guided separation of the methanol extract of Calophyllum scriblitifolium bark led to the isolation of five new pyranocoumarins, caloforines A–E (1–5) and two new coumarins, caloforines F and G (6 and 7). Their structures were elucidated by 1D and 2D NMR spectroscopy, and their absolute configurations were investigated by a combination of CD spectroscopy and DFT calculation. Caloforines A–F (1–6) showed moderate antimalarial activity against Plasmodium falciparum 3D7 strain. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11418-022-01613-6.

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