Caloforines A–G, coumarins from the bark of Calophyllum scriblitifolium

Bioactivity-guided separation of the methanol extract of Calophyllum scriblitifolium bark led to the isolation of five new pyranocoumarins, caloforines A–E (1–5) and two new coumarins, caloforines F and G (6 and 7). Their structures were elucidated by 1D and 2D NMR spectroscopy, and their absolute c...

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Autores principales: Ogasawara, Ai, Noguchi, Ryo, Shigi, Takuya, Nugroho, Alfarius Eko, Hirasawa, Yusuke, Kaneda, Toshio, Tougan, Takahiro, Horii, Toshihiro, Hadi, A. Hamid A., Morita, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938217/
https://www.ncbi.nlm.nih.gov/pubmed/35316467
http://dx.doi.org/10.1007/s11418-022-01613-6
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author Ogasawara, Ai
Noguchi, Ryo
Shigi, Takuya
Nugroho, Alfarius Eko
Hirasawa, Yusuke
Kaneda, Toshio
Tougan, Takahiro
Horii, Toshihiro
Hadi, A. Hamid A.
Morita, Hiroshi
author_facet Ogasawara, Ai
Noguchi, Ryo
Shigi, Takuya
Nugroho, Alfarius Eko
Hirasawa, Yusuke
Kaneda, Toshio
Tougan, Takahiro
Horii, Toshihiro
Hadi, A. Hamid A.
Morita, Hiroshi
author_sort Ogasawara, Ai
collection PubMed
description Bioactivity-guided separation of the methanol extract of Calophyllum scriblitifolium bark led to the isolation of five new pyranocoumarins, caloforines A–E (1–5) and two new coumarins, caloforines F and G (6 and 7). Their structures were elucidated by 1D and 2D NMR spectroscopy, and their absolute configurations were investigated by a combination of CD spectroscopy and DFT calculation. Caloforines A–F (1–6) showed moderate antimalarial activity against Plasmodium falciparum 3D7 strain. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11418-022-01613-6.
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spelling pubmed-89382172022-03-22 Caloforines A–G, coumarins from the bark of Calophyllum scriblitifolium Ogasawara, Ai Noguchi, Ryo Shigi, Takuya Nugroho, Alfarius Eko Hirasawa, Yusuke Kaneda, Toshio Tougan, Takahiro Horii, Toshihiro Hadi, A. Hamid A. Morita, Hiroshi J Nat Med Original Paper Bioactivity-guided separation of the methanol extract of Calophyllum scriblitifolium bark led to the isolation of five new pyranocoumarins, caloforines A–E (1–5) and two new coumarins, caloforines F and G (6 and 7). Their structures were elucidated by 1D and 2D NMR spectroscopy, and their absolute configurations were investigated by a combination of CD spectroscopy and DFT calculation. Caloforines A–F (1–6) showed moderate antimalarial activity against Plasmodium falciparum 3D7 strain. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11418-022-01613-6. Springer Nature Singapore 2022-03-22 2022 /pmc/articles/PMC8938217/ /pubmed/35316467 http://dx.doi.org/10.1007/s11418-022-01613-6 Text en © The Author(s) under exclusive licence to The Japanese Society of Pharmacognosy 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Paper
Ogasawara, Ai
Noguchi, Ryo
Shigi, Takuya
Nugroho, Alfarius Eko
Hirasawa, Yusuke
Kaneda, Toshio
Tougan, Takahiro
Horii, Toshihiro
Hadi, A. Hamid A.
Morita, Hiroshi
Caloforines A–G, coumarins from the bark of Calophyllum scriblitifolium
title Caloforines A–G, coumarins from the bark of Calophyllum scriblitifolium
title_full Caloforines A–G, coumarins from the bark of Calophyllum scriblitifolium
title_fullStr Caloforines A–G, coumarins from the bark of Calophyllum scriblitifolium
title_full_unstemmed Caloforines A–G, coumarins from the bark of Calophyllum scriblitifolium
title_short Caloforines A–G, coumarins from the bark of Calophyllum scriblitifolium
title_sort caloforines a–g, coumarins from the bark of calophyllum scriblitifolium
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938217/
https://www.ncbi.nlm.nih.gov/pubmed/35316467
http://dx.doi.org/10.1007/s11418-022-01613-6
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