Unique Case Reports of Tooth Sensitivity After Consuming Tetrabenazine

Tooth sensitivity (TS), a common discomfort manifests as hypersensitivity, sharp and rapid pain, or shock-like sensation in response to tactile, thermal, or chemical stimuli which others perceive as normal, affecting a significant percentage of the population. Tetrabenazine, a vesicular monoamine transport 2 receptor inhibitor acting on presynaptic neuronal endings, is commonly used in acute dystonia treatment. Two cases are reported here, where the patient, after consuming tetrabenazine (TBZ), was noted to have TS after a week of treatment. On stopping TBZ and substituting it with oral anticholinergic, the adverse symptom disappeared and did not recur again. No drugs are yet known to cause TS as an adverse drug reaction, and this is the first report of drug-induced TS cases.