The Aptamer Ob2, a novel AChE inhibitor, restores cognitive deficits and alleviates amyloidogenesis in 5×FAD transgenic mice

Loss of cerebral cholinergic neurons and decreased levels of acetylcholine (ACh) are considered to be major factors causing cognitive dysfunction in Alzheimer’s disease (AD). Abnormally elevated levels of acetylcholinesterase (AChE) resulting in decreased levels of ACh are common in AD patients; thu...

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Detalles Bibliográficos
Autores principales: Liang, Zhiman, Li, Xin, Luo, Xiaoting, Luo, Hongjie, Chen, Yajun, Cai, Mingliang, Zhong, Xinxin, Fang, Yingying, Guo, Ting, Shi, Yusheng, Zhang, Xingmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938253/
https://www.ncbi.nlm.nih.gov/pubmed/35402070
http://dx.doi.org/10.1016/j.omtn.2022.02.018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938253/
https://www.ncbi.nlm.nih.gov/pubmed/35402070
http://dx.doi.org/10.1016/j.omtn.2022.02.018

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