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CRISPR-Cas9-mediated induction of large chromosomal inversions in human bronchial epithelial cells

The in vitro recapitulation of chromosomal rearrangements is a necessary tool for understanding malignancy at the molecular level. Here, we describe the targeted induction of a large chromosomal inversion (>3.7 Mbp) through CRISPR-Cas9-mediated genome editing. As inversions occur at low frequency...

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Detalles Bibliográficos
Autores principales:	Angelopoulou, Andriani, Papaspyropoulos, Angelos, Papantonis, Argyris, Gorgoulis, Vassilis G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Protocol
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938320/ https://www.ncbi.nlm.nih.gov/pubmed/35330963 http://dx.doi.org/10.1016/j.xpro.2022.101257

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