Cognitive and Electrophysiological Correlates of Working Memory Impairments in Neurofibromatosis Type 1

Neurofibromatosis 1 (NF1) is a single gene disorder associated with working Memory (WM) impairments. The aim of this study was to investigate P300 event-related potential (ERP) associated with WM in NF1. Sixteen adolescents with NF1 were compared with controls on measures of WM and EEG was recorded...

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Autores principales: Pobric, Gorana, Taylor, Jason R., Ramalingam, Hemavathy M., Pye, Emily, Robinson, Louise, Vassallo, Grace, Jung, JeYoung, Bhandary, Misty, Szumanska-Ryt, Karolina, Theodosiou, Louise, Evans, D. Gareth, Eelloo, Judith, Burkitt-Wright, Emma, Hulleman, Johan, Green, Jonathan, Garg, Shruti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938373/
https://www.ncbi.nlm.nih.gov/pubmed/33963966
http://dx.doi.org/10.1007/s10803-021-05043-3
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author Pobric, Gorana
Taylor, Jason R.
Ramalingam, Hemavathy M.
Pye, Emily
Robinson, Louise
Vassallo, Grace
Jung, JeYoung
Bhandary, Misty
Szumanska-Ryt, Karolina
Theodosiou, Louise
Evans, D. Gareth
Eelloo, Judith
Burkitt-Wright, Emma
Hulleman, Johan
Green, Jonathan
Garg, Shruti
author_facet Pobric, Gorana
Taylor, Jason R.
Ramalingam, Hemavathy M.
Pye, Emily
Robinson, Louise
Vassallo, Grace
Jung, JeYoung
Bhandary, Misty
Szumanska-Ryt, Karolina
Theodosiou, Louise
Evans, D. Gareth
Eelloo, Judith
Burkitt-Wright, Emma
Hulleman, Johan
Green, Jonathan
Garg, Shruti
author_sort Pobric, Gorana
collection PubMed
description Neurofibromatosis 1 (NF1) is a single gene disorder associated with working Memory (WM) impairments. The aim of this study was to investigate P300 event-related potential (ERP) associated with WM in NF1. Sixteen adolescents with NF1 were compared with controls on measures of WM and EEG was recorded during a WM nback task. The NF1 group showed poorer performance on measures of WM as compared to the control group. No group differences were observed in P300 amplitude at Pz, but P300 latency was shorter in the NF1 group. Topographic analyses of P300 amplitude showed group differences indicating neural processing differences in the NF1 group relative to controls, which possibly contribute to the cognitive deficits seen in this population. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10803-021-05043-3.
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spelling pubmed-89383732022-04-07 Cognitive and Electrophysiological Correlates of Working Memory Impairments in Neurofibromatosis Type 1 Pobric, Gorana Taylor, Jason R. Ramalingam, Hemavathy M. Pye, Emily Robinson, Louise Vassallo, Grace Jung, JeYoung Bhandary, Misty Szumanska-Ryt, Karolina Theodosiou, Louise Evans, D. Gareth Eelloo, Judith Burkitt-Wright, Emma Hulleman, Johan Green, Jonathan Garg, Shruti J Autism Dev Disord Original Paper Neurofibromatosis 1 (NF1) is a single gene disorder associated with working Memory (WM) impairments. The aim of this study was to investigate P300 event-related potential (ERP) associated with WM in NF1. Sixteen adolescents with NF1 were compared with controls on measures of WM and EEG was recorded during a WM nback task. The NF1 group showed poorer performance on measures of WM as compared to the control group. No group differences were observed in P300 amplitude at Pz, but P300 latency was shorter in the NF1 group. Topographic analyses of P300 amplitude showed group differences indicating neural processing differences in the NF1 group relative to controls, which possibly contribute to the cognitive deficits seen in this population. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10803-021-05043-3. Springer US 2021-05-08 2022 /pmc/articles/PMC8938373/ /pubmed/33963966 http://dx.doi.org/10.1007/s10803-021-05043-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Paper
Pobric, Gorana
Taylor, Jason R.
Ramalingam, Hemavathy M.
Pye, Emily
Robinson, Louise
Vassallo, Grace
Jung, JeYoung
Bhandary, Misty
Szumanska-Ryt, Karolina
Theodosiou, Louise
Evans, D. Gareth
Eelloo, Judith
Burkitt-Wright, Emma
Hulleman, Johan
Green, Jonathan
Garg, Shruti
Cognitive and Electrophysiological Correlates of Working Memory Impairments in Neurofibromatosis Type 1
title Cognitive and Electrophysiological Correlates of Working Memory Impairments in Neurofibromatosis Type 1
title_full Cognitive and Electrophysiological Correlates of Working Memory Impairments in Neurofibromatosis Type 1
title_fullStr Cognitive and Electrophysiological Correlates of Working Memory Impairments in Neurofibromatosis Type 1
title_full_unstemmed Cognitive and Electrophysiological Correlates of Working Memory Impairments in Neurofibromatosis Type 1
title_short Cognitive and Electrophysiological Correlates of Working Memory Impairments in Neurofibromatosis Type 1
title_sort cognitive and electrophysiological correlates of working memory impairments in neurofibromatosis type 1
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938373/
https://www.ncbi.nlm.nih.gov/pubmed/33963966
http://dx.doi.org/10.1007/s10803-021-05043-3
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