Using CRISPR-Kill for organ specific cell elimination by cleavage of tandem repeats

CRISPR/Cas has been mainly used for mutagenesis through the induction of double strand breaks (DSBs) within unique protein-coding genes. Using the SaCas9 nuclease to induce multiple DSBs in functional repetitive DNA of Arabidopsis thaliana, we can now show that cell death can be induced in a control...

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Detalles Bibliográficos
Autores principales: Schindele, Angelina, Gehrke, Fabienne, Schmidt, Carla, Röhrig, Sarah, Dorn, Annika, Puchta, Holger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938420/
https://www.ncbi.nlm.nih.gov/pubmed/35314679
http://dx.doi.org/10.1038/s41467-022-29130-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938420/
https://www.ncbi.nlm.nih.gov/pubmed/35314679
http://dx.doi.org/10.1038/s41467-022-29130-w

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