Fatty acid oxidation fuels glioblastoma radioresistance with CD47-mediated immune evasion

Glioblastoma multiforme (GBM) remains the top challenge to radiotherapy with only 25% one-year survival after diagnosis. Here, we reveal that co-enhancement of mitochondrial fatty acid oxidation (FAO) enzymes (CPT1A, CPT2 and ACAD9) and immune checkpoint CD47 is dominant in recurrent GBM patients wi...

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Detalles Bibliográficos
Autores principales: Jiang, Nian, Xie, Bowen, Xiao, Wenwu, Fan, Ming, Xu, Shanxiu, Duan, Yixin, Hamsafar, Yamah, Evans, Angela C., Huang, Jie, Zhou, Weibing, Lin, Xuelei, Ye, Ningrong, Wanggou, Siyi, Chen, Wen, Jing, Di, Fragoso, Ruben C., Dugger, Brittany N., Wilson, Paul F., Coleman, Matthew A., Xia, Shuli, Li, Xuejun, Sun, Lun-Quan, Monjazeb, Arta M., Wang, Aijun, Murphy, William J., Kung, Hsing-Jien, Lam, Kit S., Chen, Hong-Wu, Li, Jian Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938495/
https://www.ncbi.nlm.nih.gov/pubmed/35314680
http://dx.doi.org/10.1038/s41467-022-29137-3

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