Spatiotemporal reprogramming of differentiated cells underlies regeneration and neoplasia in the intestinal epithelium

Although the mammalian intestinal epithelium manifests robust regenerative capacity after various cytotoxic injuries, the underlying mechanism has remained unclear. Here we identify the cyclin-dependent kinase inhibitor p57 as a specific marker for a quiescent cell population located around the +4 p...

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Detalles Bibliográficos
Autores principales: Higa, Tsunaki, Okita, Yasutaka, Matsumoto, Akinobu, Nakayama, Shogo, Oka, Takeru, Sugahara, Osamu, Koga, Daisuke, Takeishi, Shoichiro, Nakatsumi, Hirokazu, Hosen, Naoki, Robine, Sylvie, Taketo, Makoto M., Sato, Toshiro, Nakayama, Keiichi I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938507/
https://www.ncbi.nlm.nih.gov/pubmed/35314700
http://dx.doi.org/10.1038/s41467-022-29165-z

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