Endothelial pannexin-1 channels modulate macrophage and smooth muscle cell activation in abdominal aortic aneurysm formation

Pannexin-1 (Panx1) channels have been shown to regulate leukocyte trafficking and tissue inflammation but the mechanism of Panx1 in chronic vascular diseases like abdominal aortic aneurysms (AAA) is unknown. Here we demonstrate that Panx1 on endothelial cells, but not smooth muscle cells, orchestrat...

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Detalles Bibliográficos
Autores principales: Filiberto, Amanda C., Spinosa, Michael D., Elder, Craig T., Su, Gang, Leroy, Victoria, Ladd, Zachary, Lu, Guanyi, Mehaffey, J. Hunter, Salmon, Morgan D., Hawkins, Robert B., Ravichandran, Kodi S., Isakson, Brant E., Upchurch, Gilbert R., Sharma, Ashish K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938517/
https://www.ncbi.nlm.nih.gov/pubmed/35315432
http://dx.doi.org/10.1038/s41467-022-29233-4

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