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Empagliflozin attenuates cardiac microvascular ischemia/reperfusion through activating the AMPKα1/ULK1/FUNDC1/mitophagy pathway

Mitophagy preserves microvascular structure and function during myocardial ischemia/reperfusion (I/R) injury. Empagliflozin, an anti-diabetes drug, may also protect mitochondria. We explored whether empagliflozin could reduce cardiac microvascular I/R injury by enhancing mitophagy. In mice, I/R inju...

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Detalles Bibliográficos
Autores principales:	Cai, Chen, Guo, Zhongzhou, Chang, Xing, Li, Ziying, Wu, Feng, He, Jing, Cao, Tiantian, Wang, Kangrong, Shi, Nengxian, Zhou, Hao, Toan, Sam, Muid, David, Tan, Ying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938627/ https://www.ncbi.nlm.nih.gov/pubmed/35325804 http://dx.doi.org/10.1016/j.redox.2022.102288

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