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Design, synthesis and evaluation of 4,7-disubstituted 8-methoxyquinazoline derivatives as potential cytotoxic agents targeting β-catenin/TCF4 signaling pathway

Overactivation of Wnt/β-catenin signaling by accumulated β-catenin in the nucleus has been shown to play a crucial role in the etiology of cancer. Interaction of β-catenin with Transcription factor 4 (TCF4) is a key step for the activation of Wnt genes in response to upstream signals of the Wnt/β-ca...

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Detalles Bibliográficos
Autores principales:	Neogi, Kaushik, Murumkar, Prashant R., Sharma, Priyanshu, Yadav, Poonam, Tewari, Mallika, Karunagaran, Devarajan, Nayak, Prasanta Kumar, Yadav, Mange Ram
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Neoplasia Press 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938628/ https://www.ncbi.nlm.nih.gov/pubmed/35325837 http://dx.doi.org/10.1016/j.tranon.2022.101395

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